TY - JOUR
T1 - Zinc, metallothioneins, longevity
T2 - Effect of zinc supplementation on antioxidant response: A zincage study
AU - Mocchegiani, Eugenio
AU - Malavolta, Marco
AU - Giacconi, Robertina
AU - Cipriano, Catia
AU - Costarelli, Laura
AU - Muti, Elisa
AU - Tesei, Silvia
AU - Giuli, Cinzia
AU - Papa, Roberta
AU - Marcellini, Fiorella
AU - Mariani, Erminia
AU - Rink, Lothar
AU - Herbein, George
AU - Fulop, Tamas
AU - Monti, Daniela
AU - Jajte, Jolanta
AU - Dedoussis, George
AU - Gonos, Efstathios S.
AU - Buerkle, Alexander
AU - Friguet, Betrand
AU - Mecocci, Patrizia
AU - Colasanti, Marco
AU - Soti, Csaba
AU - Mazzatti, Dawn
AU - Blasco, Maria
AU - Aspinall, Richard
AU - Pawelec, Graham
AU - The Zincage Consortium
PY - 2008/4/28
Y1 - 2008/4/28
N2 - Aging is characterized by spontaneous biochemical changes that may predispose to increased susceptibility to diseases. Zinc may remodel these changes leading to healthy aging because zinc improves antioxidant defense via CLU protein and genomic stability via PARP-1 nuclear enzyme and repairs oxidized proteins via Msr A protein. The intracellular zinc homeostasis is regulated by metallothioneins (MT), which are unable in zinc release in aging, causing impaired antioxidant response restored by zinc supplementation. Here, the choice of old subjects for zinc supplementation is discussed in relation to their genetic background of MT and IL-6, because both affect intracellular zinc homeostasis.
AB - Aging is characterized by spontaneous biochemical changes that may predispose to increased susceptibility to diseases. Zinc may remodel these changes leading to healthy aging because zinc improves antioxidant defense via CLU protein and genomic stability via PARP-1 nuclear enzyme and repairs oxidized proteins via Msr A protein. The intracellular zinc homeostasis is regulated by metallothioneins (MT), which are unable in zinc release in aging, causing impaired antioxidant response restored by zinc supplementation. Here, the choice of old subjects for zinc supplementation is discussed in relation to their genetic background of MT and IL-6, because both affect intracellular zinc homeostasis.
UR - https://www.scopus.com/pages/publications/42649142261
U2 - 10.1089/rej.2008.0686
DO - 10.1089/rej.2008.0686
M3 - Article
C2 - 18442325
AN - SCOPUS:42649142261
SN - 1549-1684
VL - 11
SP - 419
EP - 423
JO - Rejuvenation Research
JF - Rejuvenation Research
IS - 2
ER -