Zinc, metallothioneins, longevity: Effect of zinc supplementation on antioxidant response: A zincage study

Eugenio Mocchegiani, The Zincage Consortium

Research output: Contribution to journalArticle

6 Citations (Scopus)


Aging is characterized by spontaneous biochemical changes that may predispose to increased susceptibility to diseases. Zinc may remodel these changes leading to healthy aging because zinc improves antioxidant defense via CLU protein and genomic stability via PARP-1 nuclear enzyme and repairs oxidized proteins via Msr A protein. The intracellular zinc homeostasis is regulated by metallothioneins (MT), which are unable in zinc release in aging, causing impaired antioxidant response restored by zinc supplementation. Here, the choice of old subjects for zinc supplementation is discussed in relation to their genetic background of MT and IL-6, because both affect intracellular zinc homeostasis.

Original languageEnglish
Pages (from-to)419-423
Number of pages5
JournalRejuvenation Research
Issue number2
Publication statusPublished - 28 Apr 2008


ASJC Scopus subject areas

  • Ageing
  • Geriatrics and Gerontology

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