Whole grain cereals for the primary or secondary prevention of cardiovascular disease. The Cochrane database of systematic reviews

S.A Kelly, L Hartley, E Loveman, J.L Colquitt, Helen Jones, Lena Al-Khudairy, C Clar, R Germano, H. R Lunn, G Frost, K Rees

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Background

Whole grain foods encompass a range of products and include whole grain wheat, rice, maize, and oats. The term 'whole grain' also includes milled whole grains such as oatmeal and wholemeal wheat.

Study characteristics

We evaluated nine randomised studies assessing the effects of whole grain diets compared to diets with refined grains or a usual diet on levels of cholesterol in the blood or blood pressure (major risk factors for cardiovascular disease including heart attacks or stroke). The evidence is current to August 2016.

Key results

The diets were followed for at least 12 weeks, but most studies had some methodological limitations, numbers of participants were small, and the overall quality of the evidence was low. We found no studies reporting on the effect of whole grains on deaths from cardiovascular disease or cardiovascular events. All nine included studies reported the effects of whole grain diets on levels of cholesterol in the blood or blood pressure. We found no effects on blood cholesterol or blood pressure in favour of whole grain diets. Four studies were funded by independent national and government funding bodies, while the remaining studies reported funding or partial funding by organisations with commercial interests in cereals.

Conclusion

There is insufficient evidence from randomised controlled trials to date to recommend consumption of whole grain diets to reduce the risk of cardiovascular disease, or lower blood cholesterol, or blood pressure.
Original languageEnglish
Article number3rd Publication
JournalCochrane Database of Systematic Reviews
Volume8
DOIs
Publication statusPublished - 24 Aug 2017

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Primary Prevention
Secondary Prevention
Cardiovascular Diseases
Databases
Diet
Cholesterol
Blood Pressure
Triticum
Federal Government
Whole Grains
Zea mays
Randomized Controlled Trials
Stroke
Myocardial Infarction
Organizations
Food

Cite this

Whole grain cereals for the primary or secondary prevention of cardiovascular disease. The Cochrane database of systematic reviews. / Kelly, S.A ; Hartley, L; Loveman, E; Colquitt, J.L ; Jones, Helen; Al-Khudairy, Lena; Clar, C; Germano, R; Lunn, H. R; Frost, G; Rees, K.

In: Cochrane Database of Systematic Reviews, Vol. 8, 3rd Publication, 24.08.2017.

Research output: Contribution to journalArticle

Kelly, SA, Hartley, L, Loveman, E, Colquitt, JL, Jones, H, Al-Khudairy, L, Clar, C, Germano, R, Lunn, HR, Frost, G & Rees, K 2017, 'Whole grain cereals for the primary or secondary prevention of cardiovascular disease. The Cochrane database of systematic reviews' Cochrane Database of Systematic Reviews, vol. 8, 3rd Publication. https://doi.org/10.1002/14651858.CD005051.pub3
Kelly, S.A ; Hartley, L ; Loveman, E ; Colquitt, J.L ; Jones, Helen ; Al-Khudairy, Lena ; Clar, C ; Germano, R ; Lunn, H. R ; Frost, G ; Rees, K. / Whole grain cereals for the primary or secondary prevention of cardiovascular disease. The Cochrane database of systematic reviews. In: Cochrane Database of Systematic Reviews. 2017 ; Vol. 8.
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abstract = "BackgroundWhole grain foods encompass a range of products and include whole grain wheat, rice, maize, and oats. The term 'whole grain' also includes milled whole grains such as oatmeal and wholemeal wheat.Study characteristicsWe evaluated nine randomised studies assessing the effects of whole grain diets compared to diets with refined grains or a usual diet on levels of cholesterol in the blood or blood pressure (major risk factors for cardiovascular disease including heart attacks or stroke). The evidence is current to August 2016.Key resultsThe diets were followed for at least 12 weeks, but most studies had some methodological limitations, numbers of participants were small, and the overall quality of the evidence was low. We found no studies reporting on the effect of whole grains on deaths from cardiovascular disease or cardiovascular events. All nine included studies reported the effects of whole grain diets on levels of cholesterol in the blood or blood pressure. We found no effects on blood cholesterol or blood pressure in favour of whole grain diets. Four studies were funded by independent national and government funding bodies, while the remaining studies reported funding or partial funding by organisations with commercial interests in cereals.ConclusionThere is insufficient evidence from randomised controlled trials to date to recommend consumption of whole grain diets to reduce the risk of cardiovascular disease, or lower blood cholesterol, or blood pressure.",
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AU - Kelly, S.A

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AU - Loveman, E

AU - Colquitt, J.L

AU - Jones, Helen

AU - Al-Khudairy, Lena

AU - Clar, C

AU - Germano, R

AU - Lunn, H. R

AU - Frost, G

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N2 - BackgroundWhole grain foods encompass a range of products and include whole grain wheat, rice, maize, and oats. The term 'whole grain' also includes milled whole grains such as oatmeal and wholemeal wheat.Study characteristicsWe evaluated nine randomised studies assessing the effects of whole grain diets compared to diets with refined grains or a usual diet on levels of cholesterol in the blood or blood pressure (major risk factors for cardiovascular disease including heart attacks or stroke). The evidence is current to August 2016.Key resultsThe diets were followed for at least 12 weeks, but most studies had some methodological limitations, numbers of participants were small, and the overall quality of the evidence was low. We found no studies reporting on the effect of whole grains on deaths from cardiovascular disease or cardiovascular events. All nine included studies reported the effects of whole grain diets on levels of cholesterol in the blood or blood pressure. We found no effects on blood cholesterol or blood pressure in favour of whole grain diets. Four studies were funded by independent national and government funding bodies, while the remaining studies reported funding or partial funding by organisations with commercial interests in cereals.ConclusionThere is insufficient evidence from randomised controlled trials to date to recommend consumption of whole grain diets to reduce the risk of cardiovascular disease, or lower blood cholesterol, or blood pressure.

AB - BackgroundWhole grain foods encompass a range of products and include whole grain wheat, rice, maize, and oats. The term 'whole grain' also includes milled whole grains such as oatmeal and wholemeal wheat.Study characteristicsWe evaluated nine randomised studies assessing the effects of whole grain diets compared to diets with refined grains or a usual diet on levels of cholesterol in the blood or blood pressure (major risk factors for cardiovascular disease including heart attacks or stroke). The evidence is current to August 2016.Key resultsThe diets were followed for at least 12 weeks, but most studies had some methodological limitations, numbers of participants were small, and the overall quality of the evidence was low. We found no studies reporting on the effect of whole grains on deaths from cardiovascular disease or cardiovascular events. All nine included studies reported the effects of whole grain diets on levels of cholesterol in the blood or blood pressure. We found no effects on blood cholesterol or blood pressure in favour of whole grain diets. Four studies were funded by independent national and government funding bodies, while the remaining studies reported funding or partial funding by organisations with commercial interests in cereals.ConclusionThere is insufficient evidence from randomised controlled trials to date to recommend consumption of whole grain diets to reduce the risk of cardiovascular disease, or lower blood cholesterol, or blood pressure.

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