Wettability and osteoblast cell response modulation through UV laser processing of nylon 6,6

D. G. Waugh, J. Lawrence

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)


With an ageing population the demand for cheap, efficient implants is ever increasing. Laser surface treatment offers a unique means of varying biomimetic properties to determine generic parameters to predict cell responses. This paper details how a KrF excimer laser can be employed for both laser-induced patterning and whole area irradiative processing to modulate the wettability characteristics and osteoblast cell response following 24 h and 4 day incubation. Through white light interferometry (WLI) it was found that the surface roughness had considerably increased by up to 1.5 μm for the laser-induced patterned samples and remained somewhat constant at around 0.1 μm for the whole area irradiative processed samples. A sessile drop device determined that the wettability characteristics differed between the surface treatments. For the patterned samples the contact angle, θ, increased by up to 25° which can be attributed to a mixed-state wetting regime. For the whole area irradiative processed samples θ decreased owed to an increase in polar component, γ P . For all samples θ was a decreasing function of the surface energy. The laser whole area irradiative processed samples gave rise to a distinct correlative trend between the cell response, θ and γ P . However, no strong relationship was determined for the laser-induced patterned samples due to the mixed-state wetting regime. As a result, owed to the relationships and evidence of cell differentiation one can deduce that laser whole area irradiative processing is an attractive technology for employment within regenerative medicine to meet the demands of an ageing population.

Original languageEnglish
Pages (from-to)8798-8812
Number of pages15
JournalApplied Surface Science
Issue number21
Early online date13 Jun 2011
Publication statusPublished - 15 Aug 2011
Externally publishedYes

Bibliographical note

NOTICE: this is the author’s version of a work that was accepted for publication in Applied Surface Science. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Applied Surface Science, Vol. 257, No. 21, (2011) DOI: 10.1016/j.apsusc.2011.04.044

© 2011, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/


  • Bioactivity
  • Excimer laser
  • Nylon 6,6
  • Osteoblast cells
  • Regenerative medicine
  • Wettability

ASJC Scopus subject areas

  • Surfaces, Coatings and Films


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