Waveforms of molecular oscillations reveal circadian timekeeping mechanisms

Hang-Hyun Jo, Yeon Jeong Kim, Jae Kyoung Kim, Mathias Foo, David E Somers, Pan-Jun Kim

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Abstract

Circadian clocks play a pivotal role in orchestrating numerous physiological and develop-mental events. Waveform shapes of the oscillations of protein abundances can be informative about the underlying biochemical processes of circadian clocks. We derive a mathematical framework where waveforms do reveal hidden biochemical mechanisms of circadian timekeeping. We find that the cost of synthesizing proteins with particular wave-forms can be substantially reduced by rhythmic protein half-lives over time, as supported by previous plant and mammalian data, as well as our own seedling experiment. We also find that previously enigmatic, cyclic expression of positive arm components within the mammalian and insect clocks allows both a broad range of peak time differences between protein waveforms and the symmetries of the waveforms about the peak times. Such various peak-time differences may facilitate tissue-specific or developmental stage-specific multicellular processes. Our waveform-guided approach can be extended to various biological oscillators,including cell-cycle and synthetic genetic oscillators.
Original languageEnglish
Number of pages11
JournalCommunications Biology
Volume1
Issue number207
DOIs
Publication statusPublished - 26 Nov 2018

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Circadian Clocks
Proteins
Biochemical Phenomena
Biological Clocks
Seedlings
Insects
Cell Cycle
Costs and Cost Analysis

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This article is licensed under a Creative Commons
Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Waveforms of molecular oscillations reveal circadian timekeeping mechanisms. / Jo, Hang-Hyun; Kim, Yeon Jeong; Kim, Jae Kyoung; Foo, Mathias; Somers, David E; Kim, Pan-Jun.

In: Communications Biology, Vol. 1, No. 207, 26.11.2018.

Research output: Contribution to journalArticle

Jo, Hang-Hyun ; Kim, Yeon Jeong ; Kim, Jae Kyoung ; Foo, Mathias ; Somers, David E ; Kim, Pan-Jun. / Waveforms of molecular oscillations reveal circadian timekeeping mechanisms. In: Communications Biology. 2018 ; Vol. 1, No. 207.
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