Vascular thymus transplantation in rats: Technique, morphology, and function

Jaap Kampinga, Henk Jan Schuurman, Gerda H. Pol, Hans Bartels, Roel Broekhuizen, Lennard M.B. Vaessen, Frans J. Tielen, Jan Rozing, Egbert H. Blaauw, Bruce Roser, Richard Aspinall, Paul Nieuwenhuis

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Abstract

A new method of thymus transplantation is introduced, in which the graft is directly connected with the recipient’s vascular system. This procedure was used both in euthymic rats and congenitally athymic nude rats. At all tested intervals after transplantation thymus grafts hardly differed from the recipient’s own thymus in immunohistology and lymphocyte yield. In athymic nude rats, T cell-dependent immunity, tested by mitogen- and alloantigen-induced T cell responses, as well as by antibody production and delayed-type hypersen- sivity after ovalbumin administration, showed that vascular thymus grafts could generate T cell functions to euthymic control levels. We conclude that the technique of vascular thymus transplantation represents a valuable tool, either in fundamental research on thymus function, or for the purpose of immune (re)constitution.

Original languageEnglish
Pages (from-to)669-678
Number of pages10
JournalTransplantation
Volume50
Issue number4
Publication statusPublished - Oct 1990
Externally publishedYes

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ASJC Scopus subject areas

  • Transplantation

Cite this

Kampinga, J., Schuurman, H. J., Pol, G. H., Bartels, H., Broekhuizen, R., Vaessen, L. M. B., ... Nieuwenhuis, P. (1990). Vascular thymus transplantation in rats: Technique, morphology, and function. Transplantation, 50(4), 669-678.