Variants of the cry 1 gene may influence the effect of fat intake on resting metabolic rate in women with overweight of obesity: a cross-sectional study

Atieh Mirzababaei, Elnaz Daneshzad, Farideh Shiraseb, Sanaz Pourreza, Leila Setayesh, Cain C.T. Clark, Hadith Tangestani, Faezeh Abaj, Habib Yarizadeh, Khadijeh Mirzaei

    Research output: Contribution to journalArticlepeer-review

    3 Citations (Scopus)
    26 Downloads (Pure)


    Background: Previous studies have shown that the minor allele (C allele) for Cry 1 rs2287161, may be associated with increased risk of cardiovascular diseases (CVDs). Low resting metabolic rate (RMR) caused by the diet has been shown to have, potentially, unfavorable effects on obesity. This study sought to investigate the interactions between the Cry 1 Gene and fat intake on RMR in women with overweight of obesity. Methods: This comparative cross-sectional study was conducted on 377 Iranian women with overweight of obesity. A food frequency questionnaire (FFQ), with 147 items, was used to assess dietary intake. Individuals were categorized into two groups based on the rs2287161 genotype. Body composition, dietary intake, and RMR were assessed for all participants. Results: There was a significant difference between genotypes for fasting blood sugar (FBS) (P = 0.04), fat free mass (FFM) (P = 0.0009), RMR per FFM (P = 0.05), RMR per body mass index (BMI) (P = 0.02), and RMR deviation (P = 0.01). Our findings also showed significant interactions between total fat and C allele carrier group on RMR per kg body weight, RMR per body surface area (BSA), RMR per FFM, and RMR deviation (P for interaction < 0.1), in addition to a significant interaction between CC + CG group genotype and polyunsaturated fatty acids (PUFA) intake on RMR per BMI (P for interaction =0.00) and RMR per kg (P for interaction = 0.02) and RMR per BSA (P = 0.07), compared to the GG group, after control for confounder factors. Conclusion: These results highlight that dietary compositions, gene variants, and their interaction, should be acutely considered in lower RMR.

    Original languageEnglish
    Article number196
    JournalBMC Endocrine Disorders
    Issue number1
    Early online date5 Oct 2021
    Publication statusPublished - Dec 2021

    Bibliographical note

    Funding Information:
    This study was supported by Tehran University of Medical Sciences (Grant number: 97–03–161-41144).

    Publisher Copyright:
    © 2021, The Author(s).


    • Cry 1
    • Fat intake
    • Interaction
    • Obesity
    • Overweight
    • PUFA
    • Resting metabolic rate
    • SFA

    ASJC Scopus subject areas

    • Endocrinology, Diabetes and Metabolism


    Dive into the research topics of 'Variants of the cry 1 gene may influence the effect of fat intake on resting metabolic rate in women with overweight of obesity: a cross-sectional study'. Together they form a unique fingerprint.

    Cite this