Vaccination in the elderly: What can be recommended?

Pierre Olivier Lang, Richard Aspinall

Research output: Contribution to journalReview articlepeer-review

23 Citations (Scopus)


The age-associated increased susceptibility to infectious disease would suggest that vaccination should be a route to promote healthy aging and keep our seniors autonomous and independent. While vaccination represents a cost-effective and efficient strategy at community level, the ability of the immune system to mount a protective immune response is still unpredictable at the level of the individual. Thus, at a similar age, some individuals, including the elderly, might still be 'good' responders while some other, even younger, would definitely fail to mount a protective response. In this review, the current burden of vaccine-preventable diseases in the aging and aged population will be detailed with the aim to identify the ideal vaccine candidates over the age of 50 years. This article will conclude with potential strategies to reduce, as best as possible, this burden and the imperative need to overcome barriers in extending current vaccine coverage towards to a lifelong vaccine schedule.

Original languageEnglish
Pages (from-to)581-599
Number of pages19
JournalDrugs and Aging
Issue number8
Early online date14 Jun 2014
Publication statusPublished - 2014
Externally publishedYes

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Pharmacology (medical)


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