Understanding Principles of the Dynamic Biochemical Networks of Life Through Systems Biology

Hans V. Westerhoff, Fei He, Ettore Murabito, Frédéric Crémazy, Matteo Barberis

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Citations (Scopus)

Abstract

Systems Biology brings the potential to discover fundamental principles of Life that cannot be discovered by considering individual molecules. This chapter discusses a number of early, more recent, and upcoming discoveries of such network principles. These range from the balancing of fluxes through metabolic networks, the potential of those networks for truly individualized medicine, the time dependent control of fluxes and concentrations in metabolism and signal transduction, the ways in which organisms appear to regulate metabolic processes vis-à-vis limitations therein, tradeoffs in robustness and fragility, and a relation between robustness and time dependences in the cell cycle. The robustness considerations will lead to the issue whether and how evolution has been able to put in place design principles of control engineering such as infinite robustness and perfect adaptation in the hierarchical biochemical networks of cell biology

Original languageEnglish
Title of host publicationComputational Systems Biology
Subtitle of host publicationFrom Molecular Mechanisms to Disease: Second Edition
EditorsAndres Kriete, Roland Eils
PublisherElsevier
Chapter3
Pages21-44
Number of pages24
Edition2
ISBN (Electronic)9780124059382
ISBN (Print)9780124059269
DOIs
Publication statusPublished - 12 Dec 2013
Externally publishedYes

Keywords

  • Cell cycle
  • Flux Balance Analysis (FBA)
  • Flux control coefficients
  • Fragility
  • Metabolic network
  • Objective-based modelling
  • Perfect adaptation
  • Robustness
  • Topology

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Westerhoff, H. V., He, F., Murabito, E., Crémazy, F., & Barberis, M. (2013). Understanding Principles of the Dynamic Biochemical Networks of Life Through Systems Biology. In A. Kriete, & R. Eils (Eds.), Computational Systems Biology: From Molecular Mechanisms to Disease: Second Edition (2 ed., pp. 21-44). Elsevier. https://doi.org/10.1016/B978-0-12-405926-9.00003-4