Understanding neurotransmitter receptors: Molecular biology-based strategies

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

• Neurotransmitter receptor proteins can be divided into GPCRs and ligand-gated ion channels. Members within each family utilize a similar signalling mechanism and are structurally related. • Multiple receptor subtypes are expressed for individual neurotransmitters, generating orders of complexity that have been exploited for therapeutic intervention. • GPCRs have been cloned and extensively studied by using a range of molecular biological strategies, particularly recombinant expression systems. These have located functional domains for ligand binding and G-protein coupling. • A combination of molecular biology and computer modelling has increased our understanding of receptor activation and will aid drug design.

Original languageEnglish
Pages (from-to)15-27
Number of pages13
JournalEssays in biochemistry
Volume33
DOIs
Publication statusPublished - Jan 1998
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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