Transition-metal-free catalytic synthesis of 1,5-diaryl-1,2,3-triazoles

Sen W. Kwok, Joseph R. Fotsing, Rebecca J. Fraser, Valentin O. Rodionov, Valery V. Fokin

Research output: Contribution to journalArticlepeer-review

223 Citations (Scopus)


Figure Presented. 1,5-Diarylsubstituted 1,2,3-triazoles are formed in high yield from aryl azides and terminal alkynes in DMSO in the presence of catalytic tetraalkylammonium hydroxide. The reaction is experimentally simple, does not require a transition-metal catalyst, and is not sensitive to atmospheric oxygen and moisture.

Original languageEnglish
Pages (from-to)4217-4219
Number of pages3
JournalOrganic Letters
Issue number19
Early online date8 Sept 2010
Publication statusPublished - 1 Oct 2010
Externally publishedYes


  • Catalysis
  • Hydroxides/chemistry
  • Molecular Structure
  • Transition Elements/chemistry
  • Triazoles/chemical synthesis

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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