Transcriptomic, lipid, and histological profiles suggest changes in health in fish from a pesticide hot spot.

S. E. Hook, Julie Mondon, Andrew T Revill, Paul A Greenfield, Rachael A. Smith, Ryan D.R. Turner, Patricia Corbett, Michael Warne

    Research output: Contribution to journalArticlepeer-review

    14 Citations (Scopus)
    200 Downloads (Pure)

    Abstract

    Barramundi (Lates calcarifer) were collected at the beginning (1st sampling) and end (2nd sampling) of the wet season from Sandy Creek, an agriculturally impacted catchment in the Mackay Whitsundays region of the Great Barrier Reef catchment area, and from Repulse Creek, located in a nearby national park, to assess the impacts of pesticide exposure. Gill and liver histology, lipid class composition in muscle, and the hepatic transcriptome were examined. The first sample of Repulse Creek fish showed little tissue damage and low transcript levels of xenobiotic metabolism enzymes. Sandy Creek fish showed altered transcriptomic patterns, including those that regulate lipid metabolism, xenobiotic metabolism, and immune response; gross histological alterations including lipidosis; and differences in some lipid classes. The second sampling of Repulse Creek fish showed similar alterations in hepatic transcriptome and tissue structure as fish from Sandy Creek. These changes may indicate a decrease in health of pesticide exposed fish.
    Original languageEnglish
    Pages (from-to)299-321
    Number of pages23
    JournalMarine Environmental Research
    Volume140
    Early online date30 Jun 2018
    DOIs
    Publication statusPublished - Sept 2018

    Bibliographical note

    NOTICE: this is the author’s version of a work that was accepted for publication in Marine Environmental Research. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Marine Environmental Research, 140, (2018) DOI: 10.1016/j.marenvres.2018.06.020

    Keywords

    • Atrazine
    • Diuron
    • Imidacloprid
    • RNA Seq
    • Asian sea bass (barramundi)
    • Agricultural pollution
    • Lipids
    • Pesticides

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