Tracing thymic output in older individuals

W. A. Mitchell, P. O. Lang, R. Aspinall

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

Summary As a result of age-associated thymic atrophy, T cell production declines with age. Some studies suggest that production undergoes an exponential decline starting at birth, while others consider the decline to be in a biphasic manner with a rapid reduction in output occurring before middle age followed by a phase in which output declines at a regular, albeit much slower, rate. Both approaches provide estimations of the time of termination of thymic output, but on the basis of limited amounts of data. We have analysed blood from more than 200 individuals between the ages of 58 and 104 years to determine changes in thymic output using signal-joint T cell receptor excision circles (sjTREC)/T cells as our measure. To reduce any potential geographical or nutritional bias we have obtained samples from five different European countries. Our results reveal that while the absolute number of T cells per microlitre of blood does not change significantly across the age range we tested, the values of sjTREC per microlitre show wide variation and reveal an age-associated decline in thymic output. In addition we show gender differences, with notably higher thymic output in females than males at each decade. More importantly, we noted a significant decline in sjTREC/T cell levels in those more than 90 years of age in both males and females. Our results provide information about the potential end-point for thymic output and suggest that sjTREC analysis may be a biomarker of effective ageing.

Original languageEnglish
Pages (from-to)497-503
Number of pages7
JournalClinical and Experimental Immunology
Volume161
Issue number3
Early online date14 Jul 2010
DOIs
Publication statusPublished - Sep 2010
Externally publishedYes

Keywords

  • Elderly
  • Mortality
  • Thymic output
  • Thymus TREC
  • TREC assay

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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