Towards understanding the aetiology of high myopic strabismus using mechanical analysis and finite element modelling

Haipeng Liu; Yinglan  Gong; Zhiqing Chen; Shahina Pardhan; Rajshree  Mootanah; Ling  Xia; Dingchang Zheng

doi:10.1504/IJMEI.2018.093348

Towards understanding the aetiology of high myopic strabismus using mechanical analysis and finite element modelling

Haipeng Liu, Yinglan Gong, Zhiqing Chen, Shahina Pardhan, Rajshree Mootanah, Ling Xia, Dingchang Zheng

Research output: Contribution to journal › Article › peer-review

47 Downloads (Pure)

Abstract

It has been widely accepted that the pathology of high myopic esotropia, a special form of strabismus, is still not fully understood. In this study, the mechanical analysis and finite element analysis (FEA) of the oculomotor system was based on clinical MRI data and applied to examine the physiological hypotheses of extra-ocular muscle obliquity and deformation respectively. Our mechanical analysis indicated that the muscular obliquity is not the dominated cause of high myopic strabismus. Next, by simulating the effect of different forces applied to the cross section of each extra-ocular rectus muscles, the corresponding eyeball rotations were quantified on normal eyes, and high myopic eyes with and without strabismus. The model suggests that the limitation of rotation in high myopic strabismic eyes is mainly caused by the extra-ocular muscle deformation instead of, but related with, its obliquity, providing a better understanding of the aetiology of high myopic strabismus. To the best of our knowledge, this is the first mechanical and FEA model developed from clinical data to investigate the aetiology of high myopic strabismus, providing important tools for future studies.

Original language	English
Pages (from-to)	199 - 214
Number of pages	16
Journal	International Journal of Medical Engineering and Informatics
Volume	10
Issue number	3
DOIs	https://doi.org/10.1504/IJMEI.2018.093348
Publication status	Published - 19 Jun 2018
Externally published	Yes

Bibliographical note

Copyright © and Moral Rights are retained by the author(s) and/ or other copyright owners. A copy can be downloaded for personal non-commercial research or study, without prior permission or charge. This item cannot be reproduced or quoted extensively from without first obtaining permission in writing from the copyright holder(s). The content must not be changed in any way or sold commercially in any format or medium without the formal permission of the copyright holders.

Keywords

eyeball
finite element analysis
FEA
high myopia strabismus
mechanical analysis
simulation

Access to Document

10.1504/IJMEI.2018.093348

Post-PrintAccepted author manuscript, 1.4 MBLicence: Unspecified

Cite this

@article{2a5d74bdd01f4e058b118c9322639560,

title = "Towards understanding the aetiology of high myopic strabismus using mechanical analysis and finite element modelling",

abstract = "It has been widely accepted that the pathology of high myopic esotropia, a special form of strabismus, is still not fully understood. In this study, the mechanical analysis and finite element analysis (FEA) of the oculomotor system was based on clinical MRI data and applied to examine the physiological hypotheses of extra-ocular muscle obliquity and deformation respectively. Our mechanical analysis indicated that the muscular obliquity is not the dominated cause of high myopic strabismus. Next, by simulating the effect of different forces applied to the cross section of each extra-ocular rectus muscles, the corresponding eyeball rotations were quantified on normal eyes, and high myopic eyes with and without strabismus. The model suggests that the limitation of rotation in high myopic strabismic eyes is mainly caused by the extra-ocular muscle deformation instead of, but related with, its obliquity, providing a better understanding of the aetiology of high myopic strabismus. To the best of our knowledge, this is the first mechanical and FEA model developed from clinical data to investigate the aetiology of high myopic strabismus, providing important tools for future studies.",

keywords = "eyeball, finite element analysis, FEA, high myopia strabismus, mechanical analysis, simulation",

author = "Haipeng Liu and Yinglan Gong and Zhiqing Chen and Shahina Pardhan and Rajshree Mootanah and Ling Xia and Dingchang Zheng",

note = "Copyright {\textcopyright} and Moral Rights are retained by the author(s) and/ or other copyright owners. A copy can be downloaded for personal non-commercial research or study, without prior permission or charge. This item cannot be reproduced or quoted extensively from without first obtaining permission in writing from the copyright holder(s). The content must not be changed in any way or sold commercially in any format or medium without the formal permission of the copyright holders. ",

year = "2018",

month = jun,

day = "19",

doi = "10.1504/IJMEI.2018.093348",

language = "English",

volume = "10",

pages = "199 -- 214",

journal = "International Journal of Medical Engineering and Informatics",

issn = "1755-0661",

publisher = "Inderscience Publishers",

number = "3",

}

TY - JOUR

T1 - Towards understanding the aetiology of high myopic strabismus using mechanical analysis and finite element modelling

AU - Liu, Haipeng

AU - Gong, Yinglan

AU - Chen, Zhiqing

AU - Pardhan, Shahina

AU - Mootanah, Rajshree

AU - Xia, Ling

AU - Zheng, Dingchang

N1 - Copyright © and Moral Rights are retained by the author(s) and/ or other copyright owners. A copy can be downloaded for personal non-commercial research or study, without prior permission or charge. This item cannot be reproduced or quoted extensively from without first obtaining permission in writing from the copyright holder(s). The content must not be changed in any way or sold commercially in any format or medium without the formal permission of the copyright holders.

PY - 2018/6/19

Y1 - 2018/6/19

N2 - It has been widely accepted that the pathology of high myopic esotropia, a special form of strabismus, is still not fully understood. In this study, the mechanical analysis and finite element analysis (FEA) of the oculomotor system was based on clinical MRI data and applied to examine the physiological hypotheses of extra-ocular muscle obliquity and deformation respectively. Our mechanical analysis indicated that the muscular obliquity is not the dominated cause of high myopic strabismus. Next, by simulating the effect of different forces applied to the cross section of each extra-ocular rectus muscles, the corresponding eyeball rotations were quantified on normal eyes, and high myopic eyes with and without strabismus. The model suggests that the limitation of rotation in high myopic strabismic eyes is mainly caused by the extra-ocular muscle deformation instead of, but related with, its obliquity, providing a better understanding of the aetiology of high myopic strabismus. To the best of our knowledge, this is the first mechanical and FEA model developed from clinical data to investigate the aetiology of high myopic strabismus, providing important tools for future studies.

AB - It has been widely accepted that the pathology of high myopic esotropia, a special form of strabismus, is still not fully understood. In this study, the mechanical analysis and finite element analysis (FEA) of the oculomotor system was based on clinical MRI data and applied to examine the physiological hypotheses of extra-ocular muscle obliquity and deformation respectively. Our mechanical analysis indicated that the muscular obliquity is not the dominated cause of high myopic strabismus. Next, by simulating the effect of different forces applied to the cross section of each extra-ocular rectus muscles, the corresponding eyeball rotations were quantified on normal eyes, and high myopic eyes with and without strabismus. The model suggests that the limitation of rotation in high myopic strabismic eyes is mainly caused by the extra-ocular muscle deformation instead of, but related with, its obliquity, providing a better understanding of the aetiology of high myopic strabismus. To the best of our knowledge, this is the first mechanical and FEA model developed from clinical data to investigate the aetiology of high myopic strabismus, providing important tools for future studies.

KW - eyeball

KW - finite element analysis

KW - FEA

KW - high myopia strabismus

KW - mechanical analysis

KW - simulation

UR - http://www.scopus.com/inward/record.url?eid=2-s2.0-85050677864&partnerID=MN8TOARS

U2 - 10.1504/IJMEI.2018.093348

DO - 10.1504/IJMEI.2018.093348

M3 - Article

SN - 1755-0661

VL - 10

SP - 199

EP - 214

JO - International Journal of Medical Engineering and Informatics

JF - International Journal of Medical Engineering and Informatics

IS - 3

ER -

Towards understanding the aetiology of high myopic strabismus using mechanical analysis and finite element modelling

Abstract

Bibliographical note

Keywords

Access to Document

Other files and links

Fingerprint

Cite this