Toward a PCR-independent molecular diagnosis of veterinary and medically relevant pathogenic organisms

Matthew W. Partington, Dino Masic, Audrey Nicholson, John Perry, Andrew Berrington, Jonatan West, Olivier A.E. Sparagano

Research output: Chapter in Book/Report/Conference proceedingConference proceeding

Abstract

Bloodstream infections caused by bacteria and fungi are a major problem worldwide. These bloodstream infections can affect both people and livestock, placing a significant burden upon developed and developing economies. In this paper we describe a multiplexed testing format, which can identify a range of bacteria and fungi within a single blood sample. Key to this technique is the specificity and sensitivity of the nucleotide probes that capture the sample. The sensitivity and specificity of the probes may allow detection of disease-causing microorganisms without the need for polymerase chain reaction amplification if the dynamics of probe binding can be observed in real time.

Original languageEnglish
Title of host publicationAnimal Biodiversity and Emerging Diseases Prediction and Prevention
PublisherWiley
Pages391-393
Number of pages3
Volume1149
ISBN (Print)9781573317146
DOIs
Publication statusPublished - 15 Dec 2008
Externally publishedYes

Publication series

NameAnnals of the New York Academy of Sciences
Volume1149
ISSN (Print)0077-8923
ISSN (Electronic)1749-6632

Keywords

  • Aspergillus
  • Candida
  • Diagnostics
  • PCR
  • Reverse line blot

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

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  • Cite this

    Partington, M. W., Masic, D., Nicholson, A., Perry, J., Berrington, A., West, J., & Sparagano, O. A. E. (2008). Toward a PCR-independent molecular diagnosis of veterinary and medically relevant pathogenic organisms. In Animal Biodiversity and Emerging Diseases Prediction and Prevention (Vol. 1149, pp. 391-393). (Annals of the New York Academy of Sciences; Vol. 1149). Wiley. https://doi.org/10.1196/annals.1428.010