Top research priorities in liver and gallbladder disorders in the UK

Kurinchi S. Gurusamy, Martine Walmsley, Brian R. Davidson, Claire Frier, Barry Fuller, Angela Madden, Steven Masson, Richard Morley, Ivana Safarik, Emmanuel Tsochatzis, Irfan Ahmed, Maxine Cowlin, John F. Dillon, Graham Ellicott, Ahmed M. Elsharkawy, Liz Farrington, Anthony Glachan, Nagappan Kumar, EJ Milne, Simon M. Rushbrook & 3 others Amanda Smith, Lizzie Stafford, Andrew Yeoman

Research output: Contribution to journalArticle

2 Citations (Scopus)
13 Downloads (Pure)

Abstract

Objectives There is a mismatch between research questions considered important by patients, carers and healthcare professionals and the research performed in many fields of medicine. The non-alcohol-related liver and gallbladder disorders priority setting partnership was established to identify the top research priorities in the prevention, diagnostic and treatment of gallbladder disorders and liver disorders not covered by the James Lind Alliance (JLA) alcohol-related liver disease priority setting partnership.
Design The methods broadly followed the principles of the JLA guidebook. The one major deviation from the JLA methodology was the final step of identifying priorities: instead of prioritisation by group discussions at a consensus workshop involving stakeholders, the prioritisation was achieved by a modified Delphi consensus process.
Results A total of 428 unique valid diagnostic or treatment research questions were identified. A literature review established that none of these questions were considered ‘answered’ that is, high-quality systematic reviews suggest that further research is not required on the topic. The Delphi panel achieved consensus (at least 80% Delphi panel members agreed) that a research question was a top research priority for six questions. Four additional research questions with highest proportion of Delphi panel members ranking the question as highly important were added to constitute the top 10 research priorities. Conclusions A priority setting process involving patients, carers and healthcare professionals has been used to identify the top 10priority areas for research related to liver and gallbladder disorders. Basic, translational, clinical and public health research are required to address these uncertainties.
Original languageEnglish
Article numbere025045
Number of pages9
JournalBMJ Open
Volume9
Issue number3
DOIs
Publication statusPublished - 7 Mar 2019

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Gallbladder
Liver
Research
Caregivers
Consensus Development Conferences
Health Services Research
Uncertainty
Liver Diseases
Public Health
Alcohols
Medicine
Delivery of Health Care
Therapeutics

Bibliographical note

© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

Copyright © and Moral Rights are retained by the author(s) and/ or other copyright owners. A copy can be downloaded for personal non-commercial research or study, without prior permission or charge. This item cannot be reproduced or quoted extensively from without first obtaining permission in writing from the copyright holder(s). The content must not be changed in any way

Keywords

  • Liver
  • Chronic Liver Disease
  • Delphi
  • liver
  • chronic liver disease

ASJC Scopus subject areas

  • Medicine(all)
  • Nursing(all)

Cite this

Gurusamy, K. S., Walmsley, M., Davidson, B. R., Frier, C., Fuller, B., Madden, A., ... Yeoman, A. (2019). Top research priorities in liver and gallbladder disorders in the UK. BMJ Open, 9(3), [e025045]. https://doi.org/10.1136/bmjopen-2018-025045

Top research priorities in liver and gallbladder disorders in the UK. / Gurusamy, Kurinchi S.; Walmsley, Martine; Davidson, Brian R.; Frier, Claire; Fuller, Barry ; Madden, Angela; Masson, Steven ; Morley, Richard ; Safarik, Ivana; Tsochatzis, Emmanuel ; Ahmed, Irfan ; Cowlin, Maxine; Dillon, John F. ; Ellicott, Graham; Elsharkawy, Ahmed M.; Farrington, Liz ; Glachan, Anthony; Kumar, Nagappan ; Milne, EJ; Rushbrook, Simon M.; Smith, Amanda; Stafford, Lizzie; Yeoman, Andrew.

In: BMJ Open, Vol. 9, No. 3, e025045, 07.03.2019.

Research output: Contribution to journalArticle

Gurusamy, KS, Walmsley, M, Davidson, BR, Frier, C, Fuller, B, Madden, A, Masson, S, Morley, R, Safarik, I, Tsochatzis, E, Ahmed, I, Cowlin, M, Dillon, JF, Ellicott, G, Elsharkawy, AM, Farrington, L, Glachan, A, Kumar, N, Milne, EJ, Rushbrook, SM, Smith, A, Stafford, L & Yeoman, A 2019, 'Top research priorities in liver and gallbladder disorders in the UK' BMJ Open, vol. 9, no. 3, e025045. https://doi.org/10.1136/bmjopen-2018-025045
Gurusamy KS, Walmsley M, Davidson BR, Frier C, Fuller B, Madden A et al. Top research priorities in liver and gallbladder disorders in the UK. BMJ Open. 2019 Mar 7;9(3). e025045. https://doi.org/10.1136/bmjopen-2018-025045
Gurusamy, Kurinchi S. ; Walmsley, Martine ; Davidson, Brian R. ; Frier, Claire ; Fuller, Barry ; Madden, Angela ; Masson, Steven ; Morley, Richard ; Safarik, Ivana ; Tsochatzis, Emmanuel ; Ahmed, Irfan ; Cowlin, Maxine ; Dillon, John F. ; Ellicott, Graham ; Elsharkawy, Ahmed M. ; Farrington, Liz ; Glachan, Anthony ; Kumar, Nagappan ; Milne, EJ ; Rushbrook, Simon M. ; Smith, Amanda ; Stafford, Lizzie ; Yeoman, Andrew. / Top research priorities in liver and gallbladder disorders in the UK. In: BMJ Open. 2019 ; Vol. 9, No. 3.
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AU - Fuller, Barry

AU - Madden, Angela

AU - Masson, Steven

AU - Morley, Richard

AU - Safarik, Ivana

AU - Tsochatzis, Emmanuel

AU - Ahmed, Irfan

AU - Cowlin, Maxine

AU - Dillon, John F.

AU - Ellicott, Graham

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AU - Kumar, Nagappan

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N2 - Objectives There is a mismatch between research questions considered important by patients, carers and healthcare professionals and the research performed in many fields of medicine. The non-alcohol-related liver and gallbladder disorders priority setting partnership was established to identify the top research priorities in the prevention, diagnostic and treatment of gallbladder disorders and liver disorders not covered by the James Lind Alliance (JLA) alcohol-related liver disease priority setting partnership. Design The methods broadly followed the principles of the JLA guidebook. The one major deviation from the JLA methodology was the final step of identifying priorities: instead of prioritisation by group discussions at a consensus workshop involving stakeholders, the prioritisation was achieved by a modified Delphi consensus process. Results A total of 428 unique valid diagnostic or treatment research questions were identified. A literature review established that none of these questions were considered ‘answered’ that is, high-quality systematic reviews suggest that further research is not required on the topic. The Delphi panel achieved consensus (at least 80% Delphi panel members agreed) that a research question was a top research priority for six questions. Four additional research questions with highest proportion of Delphi panel members ranking the question as highly important were added to constitute the top 10 research priorities. Conclusions A priority setting process involving patients, carers and healthcare professionals has been used to identify the top 10priority areas for research related to liver and gallbladder disorders. Basic, translational, clinical and public health research are required to address these uncertainties.

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