The zDHHC family of S-acyltransferases

Kimon Lemonidis; Martin W. Werno; Jennifer Greaves; Cinta Diez-Ardanuy; Maria C. Sanchez-Perez; Christine Salaun; David M. Thomson; Luke H. Chamberlain

doi:10.1042/BST20140270

The zDHHC family of S-acyltransferases

Kimon Lemonidis, Martin W. Werno, Jennifer Greaves, Cinta Diez-Ardanuy, Maria C. Sanchez-Perez, Christine Salaun, David M. Thomson, Luke H. Chamberlain

University of Strathclyde

Research output: Contribution to journal › Article › peer-review

43 Citations (Scopus)

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Abstract

The discovery of the zDHHC family of S-acyltransferase enzymes has been one of the major breakthroughs in the S-acylation field. Now, more than a decade since their discovery, major questions centre on profiling the substrates of individual zDHHC enzymes (there are 24 ZDHHC genes and several hundred S-acylated proteins), defining the mechanisms of enzyme-substrate specificity and unravelling the importance of this enzyme family for cellular physiology and pathology.

Original language	English
Pages (from-to)	217-221
Number of pages	5
Journal	Biochemical Society Transactions
Volume	43
DOIs	https://doi.org/10.1042/BST20140270
Publication status	Published - 7 Apr 2015
Externally published	Yes

Bibliographical note

Copyright © and Moral Rights are retained by the author(s) and/ or other copyright owners. A copy can be downloaded for personal non-commercial research or study, without prior permission or charge. This item cannot be reproduced or quoted extensively from without first obtaining permission in writing from the copyright holder(s). The content must not be changed in any way or sold commercially in any format or medium without the formal permission of the copyright holders.

Keywords

Palmitoylation zDHHC enzymes
S-acylation
Thioesterases

ASJC Scopus subject areas

Biochemistry

Access to Document

10.1042/BST20140270Licence: CC BY

Post-printAccepted author manuscript, 753 KBLicence: CC BY

Cite this

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AU - Diez-Ardanuy, Cinta

AU - Sanchez-Perez, Maria C.

AU - Salaun, Christine

AU - Thomson, David M.

AU - Chamberlain, Luke H.

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The zDHHC family of S-acyltransferases

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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