The zDHHC family of S-acyltransferases

Kimon Lemonidis, Martin W. Werno, Jennifer Greaves, Cinta Diez-Ardanuy, Maria C. Sanchez-Perez, Christine Salaun, David M. Thomson, Luke H. Chamberlain

Research output: Contribution to journalArticle

12 Citations (Scopus)
3 Downloads (Pure)

Abstract

The discovery of the zDHHC family of S-acyltransferase enzymes has been one of the major breakthroughs in the S-acylation field. Now, more than a decade since their discovery, major questions centre on profiling the substrates of individual zDHHC enzymes (there are 24 ZDHHC genes and several hundred S-acylated proteins), defining the mechanisms of enzyme-substrate specificity and unravelling the importance of this enzyme family for cellular physiology and pathology.

Original languageEnglish
Pages (from-to)217-221
Number of pages5
JournalBiochemical Society Transactions
Volume43
DOIs
Publication statusPublished - 7 Apr 2015
Externally publishedYes

Bibliographical note

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Keywords

  • Palmitoylation zDHHC enzymes
  • S-acylation
  • Thioesterases

ASJC Scopus subject areas

  • Biochemistry

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  • Cite this

    Lemonidis, K., Werno, M. W., Greaves, J., Diez-Ardanuy, C., Sanchez-Perez, M. C., Salaun, C., ... Chamberlain, L. H. (2015). The zDHHC family of S-acyltransferases. Biochemical Society Transactions, 43, 217-221. https://doi.org/10.1042/BST20140270