The zDHHC family of S-acyltransferases

Kimon Lemonidis, Martin W. Werno, Jennifer Greaves, Cinta Diez-Ardanuy, Maria C. Sanchez-Perez, Christine Salaun, David M. Thomson, Luke H. Chamberlain

Research output: Contribution to journalArticle

10 Citations (Scopus)
1 Downloads (Pure)

Abstract

The discovery of the zDHHC family of S-acyltransferase enzymes has been one of the major breakthroughs in the S-acylation field. Now, more than a decade since their discovery, major questions centre on profiling the substrates of individual zDHHC enzymes (there are 24 ZDHHC genes and several hundred S-acylated proteins), defining the mechanisms of enzyme-substrate specificity and unravelling the importance of this enzyme family for cellular physiology and pathology.

Original languageEnglish
Pages (from-to)217-221
Number of pages5
JournalBiochemical Society Transactions
Volume43
DOIs
Publication statusPublished - 7 Apr 2015
Externally publishedYes

Fingerprint

Acyltransferases
Enzymes
Acylation
Protein S
Physiology
Pathology
Substrates
Substrate Specificity
Genes
Proteins

Bibliographical note

Copyright © and Moral Rights are retained by the author(s) and/ or other copyright owners. A copy can be downloaded for personal non-commercial research or study, without prior permission or charge. This item cannot be reproduced or quoted extensively from without first obtaining permission in writing from the copyright holder(s). The content must not be changed in any way or sold commercially in any format or medium without the formal permission of the copyright holders.

Keywords

  • Palmitoylation zDHHC enzymes
  • S-acylation
  • Thioesterases

ASJC Scopus subject areas

  • Biochemistry

Cite this

Lemonidis, K., Werno, M. W., Greaves, J., Diez-Ardanuy, C., Sanchez-Perez, M. C., Salaun, C., ... Chamberlain, L. H. (2015). The zDHHC family of S-acyltransferases. Biochemical Society Transactions, 43, 217-221. https://doi.org/10.1042/BST20140270

The zDHHC family of S-acyltransferases. / Lemonidis, Kimon; Werno, Martin W.; Greaves, Jennifer; Diez-Ardanuy, Cinta; Sanchez-Perez, Maria C.; Salaun, Christine; Thomson, David M.; Chamberlain, Luke H.

In: Biochemical Society Transactions, Vol. 43, 07.04.2015, p. 217-221.

Research output: Contribution to journalArticle

Lemonidis, K, Werno, MW, Greaves, J, Diez-Ardanuy, C, Sanchez-Perez, MC, Salaun, C, Thomson, DM & Chamberlain, LH 2015, 'The zDHHC family of S-acyltransferases' Biochemical Society Transactions, vol. 43, pp. 217-221. https://doi.org/10.1042/BST20140270
Lemonidis K, Werno MW, Greaves J, Diez-Ardanuy C, Sanchez-Perez MC, Salaun C et al. The zDHHC family of S-acyltransferases. Biochemical Society Transactions. 2015 Apr 7;43:217-221. https://doi.org/10.1042/BST20140270
Lemonidis, Kimon ; Werno, Martin W. ; Greaves, Jennifer ; Diez-Ardanuy, Cinta ; Sanchez-Perez, Maria C. ; Salaun, Christine ; Thomson, David M. ; Chamberlain, Luke H. / The zDHHC family of S-acyltransferases. In: Biochemical Society Transactions. 2015 ; Vol. 43. pp. 217-221.
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