The tumour suppressing role of the circadian clock

Kate Davis, Laura C. Roden, Virna D. Leaner, Pauline J. van der Watt

Research output: Contribution to journalArticle

Abstract

The circadian clock and the ~24 h rhythms it generates are essential in maintaining regular tissue functioning. At the molecular level, the circadian clock comprises a core set of rhythmically expressed genes and gene products that are able to drive rhythmic expression of other genes to generate overt circadian rhythms. It has recently come to light that perturbations of circadian rhythms contribute to the development of pathological states such as cancer, and altered expression and/or regulation of circadian clock genes has been identified in multiple tumour types. This review summarises the important role the circadian system plays in regulating cellular processes, including the cell cycle, apoptosis, DNA repair, the epithelial‐to‐mesenchymal transition, metabolism and immunity and how its dysregulation has widespread implications and could be a critical player in the development of cancer. Understanding its role in cancer development is important for the field chronotherapy, where the timing of chemotherapy administration is optimised based on differences in circadian clock functioning in normal and cancer cells. This has been found to influence the patient response, minimising the side effects commonly associated with chemotherapy.
Original languageEnglish
Pages (from-to)771-780
Number of pages10
JournalIUBMB Life
Volume71
Issue number7
Early online date23 Jan 2019
DOIs
Publication statusPublished - Jul 2019

Fingerprint

Circadian Clocks
Tumors
Clocks
Genes
Chemotherapy
Neoplasms
Circadian Rhythm
Cells
Chronotherapy
Drug Therapy
Metabolism
Repair
DNA Repair
Tissue
Apoptosis
Immunity
Cell Cycle
DNA
Gene Expression

Keywords

  • cancer
  • circadian clock
  • tumour suppressor

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics
  • Clinical Biochemistry
  • Cell Biology

Cite this

Davis, K., Roden, L. C., Leaner, V. D., & Watt, P. J. V. D. (2019). The tumour suppressing role of the circadian clock. IUBMB Life, 71(7), 771-780. https://doi.org/10.1002/iub.2005

The tumour suppressing role of the circadian clock. / Davis, Kate; Roden, Laura C.; Leaner, Virna D.; Watt, Pauline J. van der.

In: IUBMB Life, Vol. 71, No. 7, 07.2019, p. 771-780.

Research output: Contribution to journalArticle

Davis, K, Roden, LC, Leaner, VD & Watt, PJVD 2019, 'The tumour suppressing role of the circadian clock' IUBMB Life, vol. 71, no. 7, pp. 771-780. https://doi.org/10.1002/iub.2005
Davis, Kate ; Roden, Laura C. ; Leaner, Virna D. ; Watt, Pauline J. van der. / The tumour suppressing role of the circadian clock. In: IUBMB Life. 2019 ; Vol. 71, No. 7. pp. 771-780.
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