The Role of the Vasculature in Heart Failure

Mithilesh Joshi, Patrick Tran, Thomas M Barber, Waqar Ayub, Michael Kuehl, Prithwish Banerjee

    Research output: Contribution to journalArticlepeer-review


    The contribution of the vasculature in the development and progression of heart failure (HF) syndromes is poorly understood and often neglected. Incorporating both arterial and venous systems, the vasculature plays a significant role in the regulation of blood flow throughout the body in meeting its metabolic requirements. A deterioration or imbalance between the cardiac and vascular interaction can precipitate acute decompensated HF in both preserved and reduced ejection fraction phenotypes. This is characterised by the increasingly recognised concept of ventricular-arterial coupling: a well-balanced relationship between ventricular and vascular stiffness, which has major implications in HF. Often, the cause of decompensation is unknown, with international guidelines mainly centred on arrhythmia, infection, acute coronary syndrome and its mechanical complications as common causes of decompensation; the vascular component is often underrecognised. A better understanding of the vascular contribution in cardiovascular failure can improve risk stratification, earlier diagnosis and facilitate earlier optimal treatment. This review focuses on the role of the vasculature by integrating the concepts of ventricular-arterial coupling, arterial stiffness and venous return in a failing heart. [Abstract copyright: © 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.]
    Original languageEnglish
    Pages (from-to)179-190
    Number of pages12
    JournalCurrent Heart Failure Reports
    Issue number3
    Early online date9 May 2023
    Publication statusPublished - Jun 2023


    • Cardiac and venous return curves
    • Arterial stiffness
    • Heart failure
    • Vasculature
    • Ventricular-vascular coupling


    Dive into the research topics of 'The Role of the Vasculature in Heart Failure'. Together they form a unique fingerprint.

    Cite this