The role of matrix metalloproteinase 7 in innate immunity

Research output: Contribution to journalReview article

37 Citations (Scopus)

Abstract

Matrix metalloproteinase 7 (MMP-7), or matrilysin, is a secreted protease expressed by glandular and mucosal epithelial cells, keratinocytes, fibroblasts and macrophages. As with other MMPs it can act on the extracellular matrix and thereby regulate cell migration and tissue repair. In addition, MMP-7 has an important role in the maintenance of innate immunity in organs such as the lungs and intestines where it proteolytically activates anti-bacterial peptides such as pro-defensins. MMP-7 is also important for mediating proteolytic release of TNF from macrophages. Consistent with its role in innate immunity, MMP-7 is induced by microbial products and also, unexpectedly, by hypoxia.

Original languageEnglish
Pages (from-to)51-56
Number of pages6
JournalImmunobiology
Volume209
Issue number1-2
DOIs
Publication statusPublished - 23 Aug 2004
Externally publishedYes

Fingerprint

Matrix Metalloproteinase 7
Innate Immunity
Macrophages
Defensins
Matrix Metalloproteinases
Keratinocytes
Intestines
Cell Movement
Extracellular Matrix
Peptide Hydrolases
Fibroblasts
Epithelial Cells
Maintenance
Lung
Peptides

Keywords

  • Gene Expression Regulation
  • Immunity, Innate
  • Matrix Metalloproteinase 7/immunology
  • Transcription, Genetic

Cite this

The role of matrix metalloproteinase 7 in innate immunity. / Burke, Bernard.

In: Immunobiology, Vol. 209, No. 1-2, 23.08.2004, p. 51-56.

Research output: Contribution to journalReview article

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