The role of matrix metalloproteinase 7 in innate immunity

Bernard Burke

doi:10.1016/j.imbio.2004.04.005

The role of matrix metalloproteinase 7 in innate immunity

Bernard Burke

Research output: Contribution to journal › Review article

37 Citations (Scopus)

Abstract

Matrix metalloproteinase 7 (MMP-7), or matrilysin, is a secreted protease expressed by glandular and mucosal epithelial cells, keratinocytes, fibroblasts and macrophages. As with other MMPs it can act on the extracellular matrix and thereby regulate cell migration and tissue repair. In addition, MMP-7 has an important role in the maintenance of innate immunity in organs such as the lungs and intestines where it proteolytically activates anti-bacterial peptides such as pro-defensins. MMP-7 is also important for mediating proteolytic release of TNF from macrophages. Consistent with its role in innate immunity, MMP-7 is induced by microbial products and also, unexpectedly, by hypoxia.

Original language	English
Pages (from-to)	51-56
Number of pages	6
Journal	Immunobiology
Volume	209
Issue number	1-2
DOIs	https://doi.org/10.1016/j.imbio.2004.04.005
Publication status	Published - 23 Aug 2004
Externally published	Yes

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Keywords

Gene Expression Regulation
Immunity, Innate
Matrix Metalloproteinase 7/immunology
Transcription, Genetic

Cite this

Burke, B. (2004). The role of matrix metalloproteinase 7 in innate immunity. Immunobiology, 209(1-2), 51-56. https://doi.org/10.1016/j.imbio.2004.04.005

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AB - Matrix metalloproteinase 7 (MMP-7), or matrilysin, is a secreted protease expressed by glandular and mucosal epithelial cells, keratinocytes, fibroblasts and macrophages. As with other MMPs it can act on the extracellular matrix and thereby regulate cell migration and tissue repair. In addition, MMP-7 has an important role in the maintenance of innate immunity in organs such as the lungs and intestines where it proteolytically activates anti-bacterial peptides such as pro-defensins. MMP-7 is also important for mediating proteolytic release of TNF from macrophages. Consistent with its role in innate immunity, MMP-7 is induced by microbial products and also, unexpectedly, by hypoxia.

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KW - Transcription, Genetic

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Access to Document

10.1016/j.imbio.2004.04.005