The role of matrix metalloproteinase 7 in innate immunity

Bernard Burke

doi:10.1016/j.imbio.2004.04.005

The role of matrix metalloproteinase 7 in innate immunity

Bernard Burke

Research output: Contribution to journal › Review article › peer-review

42 Citations (Scopus)

Abstract

Matrix metalloproteinase 7 (MMP-7), or matrilysin, is a secreted protease expressed by glandular and mucosal epithelial cells, keratinocytes, fibroblasts and macrophages. As with other MMPs it can act on the extracellular matrix and thereby regulate cell migration and tissue repair. In addition, MMP-7 has an important role in the maintenance of innate immunity in organs such as the lungs and intestines where it proteolytically activates anti-bacterial peptides such as pro-defensins. MMP-7 is also important for mediating proteolytic release of TNF from macrophages. Consistent with its role in innate immunity, MMP-7 is induced by microbial products and also, unexpectedly, by hypoxia.

Original language	English
Pages (from-to)	51-56
Number of pages	6
Journal	Immunobiology
Volume	209
Issue number	1-2
DOIs	https://doi.org/10.1016/j.imbio.2004.04.005
Publication status	Published - 23 Aug 2004
Externally published	Yes

Keywords

Gene Expression Regulation
Immunity, Innate
Matrix Metalloproteinase 7/immunology
Transcription, Genetic

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title = "The role of matrix metalloproteinase 7 in innate immunity",

abstract = "Matrix metalloproteinase 7 (MMP-7), or matrilysin, is a secreted protease expressed by glandular and mucosal epithelial cells, keratinocytes, fibroblasts and macrophages. As with other MMPs it can act on the extracellular matrix and thereby regulate cell migration and tissue repair. In addition, MMP-7 has an important role in the maintenance of innate immunity in organs such as the lungs and intestines where it proteolytically activates anti-bacterial peptides such as pro-defensins. MMP-7 is also important for mediating proteolytic release of TNF from macrophages. Consistent with its role in innate immunity, MMP-7 is induced by microbial products and also, unexpectedly, by hypoxia.",

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AU - Burke, Bernard

PY - 2004/8/23

Y1 - 2004/8/23

N2 - Matrix metalloproteinase 7 (MMP-7), or matrilysin, is a secreted protease expressed by glandular and mucosal epithelial cells, keratinocytes, fibroblasts and macrophages. As with other MMPs it can act on the extracellular matrix and thereby regulate cell migration and tissue repair. In addition, MMP-7 has an important role in the maintenance of innate immunity in organs such as the lungs and intestines where it proteolytically activates anti-bacterial peptides such as pro-defensins. MMP-7 is also important for mediating proteolytic release of TNF from macrophages. Consistent with its role in innate immunity, MMP-7 is induced by microbial products and also, unexpectedly, by hypoxia.

AB - Matrix metalloproteinase 7 (MMP-7), or matrilysin, is a secreted protease expressed by glandular and mucosal epithelial cells, keratinocytes, fibroblasts and macrophages. As with other MMPs it can act on the extracellular matrix and thereby regulate cell migration and tissue repair. In addition, MMP-7 has an important role in the maintenance of innate immunity in organs such as the lungs and intestines where it proteolytically activates anti-bacterial peptides such as pro-defensins. MMP-7 is also important for mediating proteolytic release of TNF from macrophages. Consistent with its role in innate immunity, MMP-7 is induced by microbial products and also, unexpectedly, by hypoxia.

KW - Gene Expression Regulation

KW - Immunity, Innate

KW - Matrix Metalloproteinase 7/immunology

KW - Transcription, Genetic

U2 - 10.1016/j.imbio.2004.04.005

DO - 10.1016/j.imbio.2004.04.005

M3 - Review article

C2 - 15481140

VL - 209

SP - 51

EP - 56

JO - Immunobiology

JF - Immunobiology

SN - 0171-2985

IS - 1-2

ER -