Abstract
Matrix metalloproteinase 7 (MMP-7), or matrilysin, is a secreted protease expressed by glandular and mucosal epithelial cells, keratinocytes, fibroblasts and macrophages. As with other MMPs it can act on the extracellular matrix and thereby regulate cell migration and tissue repair. In addition, MMP-7 has an important role in the maintenance of innate immunity in organs such as the lungs and intestines where it proteolytically activates anti-bacterial peptides such as pro-defensins. MMP-7 is also important for mediating proteolytic release of TNF from macrophages. Consistent with its role in innate immunity, MMP-7 is induced by microbial products and also, unexpectedly, by hypoxia.
| Original language | English |
|---|---|
| Pages (from-to) | 51-56 |
| Number of pages | 6 |
| Journal | Immunobiology |
| Volume | 209 |
| Issue number | 1-2 |
| DOIs | |
| Publication status | Published - 23 Aug 2004 |
| Externally published | Yes |
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Keywords
- Gene Expression Regulation
- Immunity, Innate
- Matrix Metalloproteinase 7/immunology
- Transcription, Genetic
Cite this
The role of matrix metalloproteinase 7 in innate immunity. / Burke, Bernard.
In: Immunobiology, Vol. 209, No. 1-2, 23.08.2004, p. 51-56.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - The role of matrix metalloproteinase 7 in innate immunity
AU - Burke, Bernard
PY - 2004/8/23
Y1 - 2004/8/23
N2 - Matrix metalloproteinase 7 (MMP-7), or matrilysin, is a secreted protease expressed by glandular and mucosal epithelial cells, keratinocytes, fibroblasts and macrophages. As with other MMPs it can act on the extracellular matrix and thereby regulate cell migration and tissue repair. In addition, MMP-7 has an important role in the maintenance of innate immunity in organs such as the lungs and intestines where it proteolytically activates anti-bacterial peptides such as pro-defensins. MMP-7 is also important for mediating proteolytic release of TNF from macrophages. Consistent with its role in innate immunity, MMP-7 is induced by microbial products and also, unexpectedly, by hypoxia.
AB - Matrix metalloproteinase 7 (MMP-7), or matrilysin, is a secreted protease expressed by glandular and mucosal epithelial cells, keratinocytes, fibroblasts and macrophages. As with other MMPs it can act on the extracellular matrix and thereby regulate cell migration and tissue repair. In addition, MMP-7 has an important role in the maintenance of innate immunity in organs such as the lungs and intestines where it proteolytically activates anti-bacterial peptides such as pro-defensins. MMP-7 is also important for mediating proteolytic release of TNF from macrophages. Consistent with its role in innate immunity, MMP-7 is induced by microbial products and also, unexpectedly, by hypoxia.
KW - Gene Expression Regulation
KW - Immunity, Innate
KW - Matrix Metalloproteinase 7/immunology
KW - Transcription, Genetic
U2 - 10.1016/j.imbio.2004.04.005
DO - 10.1016/j.imbio.2004.04.005
M3 - Review article
VL - 209
SP - 51
EP - 56
JO - Immunobiology
JF - Immunobiology
SN - 0171-2985
IS - 1-2
ER -