The relationship between interleukin-6 in saliva, venous and capillary plasma, at rest and in response to exercise

T. Cullen, A. W. Thomas, Richard Webb, M. G. Hughes

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17 Citations (Scopus)


IL-6 plays a mechanistic role in conditions such as metabolic syndrome, chronic fatigue syndrome and clinical depression and also plays a major role in inflammatory and immune responses to exercise. The purpose of this study was to investigate the levels of resting and post exercise IL-6 when measured in venous plasma, saliva and capillary plasma. Five male and five females completed 2 separate exercise trials, both of which involved standardized exercise sessions on a cycle ergometer. Venous blood and saliva samples were taken immediately before and after Trial A, venous and capillary blood samples were taken immediately before and after Trial B. IL-6 values were obtained using a high-sensitivity enzyme-linked immunosorbent assay (ELISA). In Trial A venous plasma IL-6 increased significantly from 0.4. ±. 0.14. pg/ml to 0.99. ±. 0.29. pg/ml (. P
Original languageEnglish
Pages (from-to)397-400
Number of pages4
Issue number2
Early online date15 Nov 2014
Publication statusPublished - 1 Feb 2015



  • Capillary
  • Cytokines
  • Exercise
  • Interluekin-6
  • Saliva

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