The relationship between dietary phytochemical index and resting metabolic rate mediated by inflammatory factors in overweight and obese women: a cross-sectional study

Atieh Mirzababaei, Akram Taheri, Niloufar Rasaei, Sanaz Mehranfar, Shahin Jamili, Cain C. T. Clark, Khadijeh Mirzaei

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Abstract

Abstract: Background: Unhealthy dietary patterns are the most important modifiable risk factors for obesity and overweight. This study aimed to examine the relationship between Dietary Phytochemical Index (DPI) and resting metabolic rate (RMR), mediated by inflammatory factors, in overweight and obese women. Methods: A total of 404 women, aged 18–48 years, were included in the cross-sectional study. DPI was calculated using the 147-item food frequency questionnaire (FFQ). Anthropometric measurements, RMR, and blood biomarkers were assessed using standard protocols. Results: There was marginally significant association between adherence to DPI and RMR status in the crude model (OR = 1.41, 95% CI 0.94–2.11, P = 0.09). After adjusting for potential confounders, a significant association was seen between the DPI and increase RMR.per.kg (OR = 2.77, 95% CI 0.98–7.82, P = 0.05). Our results indicated that plasminogen activator inhibitor-1 (PAI-1), transforming growth factor (TGF-β), and monocyte chemoattractant protein-1 (MCP-1) had a mediatory effect on the association between RMR and DPI (P > 0.05). Indeed, it was shown that, PAI-1, TGF-β, and MCP-1 destroyed the significance of this association and could be considered as mediating markers. However, no mediating effect was observed for high-sensitivity C reactive protein (hs-CRP). Conclusions: Adherence to DPI can improve the RMR by reducing levels of inflammatory markers, and may be considered as a treatment for obesity. However, more long-term studies are recommended.
Original languageEnglish
Article number313
JournalBMC Women's Health
Volume22
Issue number1
Early online date25 Jul 2022
DOIs
Publication statusE-pub ahead of print - 25 Jul 2022

Bibliographical note

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Funder

This study was financially supported by the Tehran University of Medical Sciences (Grant’s ID: 97-03-161-41155).

Keywords

  • Research
  • Resting metabolic rate
  • Obesity and overweight
  • Dietary phytochemical index
  • Inflammatory marker

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