The relationship between Dietary approaches to stop hypertension diet adherence and inflammatory factors and insulin resistance in overweight and obese women: A cross-sectional study

Akram Taheri; Atieh Mirzababaei; Leila Setayesh; Habib Yarizadeh; Farideh Shiraseb; Hossein Imani; Cain C T Clark; Khadijeh Mirzaei

doi:10.1016/j.diabres.2021.109128

The relationship between Dietary approaches to stop hypertension diet adherence and inflammatory factors and insulin resistance in overweight and obese women: A cross-sectional study

Akram Taheri, Atieh Mirzababaei, Leila Setayesh, Habib Yarizadeh, Farideh Shiraseb, Hossein Imani, Cain C T Clark, Khadijeh Mirzaei

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

BACKGROUND: Although there is abundant evidence for an association between dietary pattern, weight, and other related factors, such as homeostatic model assessment for insulin resistance (HOMA-IR) and inflammatory markers; there is limited information pertaining to levels of plasminogen activator inhibitor-1 (PAI-1) and Monocyte Chemoattractant Protein -1 (MCP-1). Therefore, this study sought to examine the association between adherence to the dietary approaches to stop hypertension (DASH) diet and levels of inflammatory factors PAI-1, MCP-1, and HOMA-IR.

METHODS: This cross-sectional study was performed on 305 obese and overweight women. The typical food intake of individuals was assessed using the 147 items semi-quantitative food frequency questionnaire (FFQ). Body components were measured for all participants. Insulin resistance was estimated by homeostasis model assessment (HOMA), and biochemical parameters were examined.

RESULTS: No significant relationship was observed between the DASH diet and MCP-1 (P-trend = 0.70), PAI-1 (P-trend = 0.92), or HOMA-IR (P-trend = 0.08) in the crude model. However, there was a significant inverse relationship between the DASH diet and HOMA-IR (P-trend = 0.03) after adjusting for age, BMI, and physical activity.

CONCLUSION: This study showed that higher adherence to DASH pattern is inversely correlated with HOMA-IR in overweight and obese women.

Original language	English
Article number	109128
Journal	Diabetes Research and Clinical Practice
Volume	182
Early online date	14 Nov 2021
DOIs	https://doi.org/10.1016/j.diabres.2021.109128
Publication status	Published - Dec 2021

Bibliographical note

Funding Information:
This study was supported by the Tehran University of Medical Sciences , and by grants from. Tehran University of Medical Sciences (Grants ID: 97-03-161-41155 and 99-3-212-51715 ).

Funding Information:
Thank you for the valuable cooperation of the officials of Tehran Health Centers in the implementation of this project, as well as for the cooperation of those who participated in data collection and nutrition evaluation. This study was supported by the Tehran University of Medical Sciences, and by grants from. Tehran University of Medical Sciences (Grants ID: 97-03-161-41155 and 99-3-212-51715). Ak.T. designed the study and collected the samples, A. M. and L. S entering FFQ data into NUTRITIONIST IV software, and wrote the paper, F. SH. revised the article, H. I. contributed to interpretation of the data and revised the article, Kh. M had full access to all of the data in the study and took responsibility for the integrity and accuracy of the data. All authors read and approved the final manuscript.

Publisher Copyright:
© 2021

Funding

Funders	Funder number
Tehran University of Medical Sciences	97-03-161-41155, 99-3-212-51715
Tehran University of Medical Sciences

Keywords

DASH
HOMA-IR
MCP-1
Obese
Overweight
PAI-1

ASJC Scopus subject areas

Internal Medicine
Endocrinology, Diabetes and Metabolism
Endocrinology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.diabres.2021.109128

Cite this

Taheri, A., Mirzababaei, A., Setayesh, L., Yarizadeh, H., Shiraseb, F., Imani, H., C T Clark, C., & Mirzaei, K. (2021). The relationship between Dietary approaches to stop hypertension diet adherence and inflammatory factors and insulin resistance in overweight and obese women: A cross-sectional study. Diabetes Research and Clinical Practice, 182, Article 109128. https://doi.org/10.1016/j.diabres.2021.109128

The relationship between Dietary approaches to stop hypertension diet adherence and inflammatory factors and insulin resistance in overweight and obese women: A cross-sectional study. / Taheri, Akram; Mirzababaei, Atieh; Setayesh, Leila et al.
In: Diabetes Research and Clinical Practice, Vol. 182, 109128, 12.2021.

Research output: Contribution to journal › Article › peer-review

Taheri, A, Mirzababaei, A, Setayesh, L, Yarizadeh, H, Shiraseb, F, Imani, H, C T Clark, C & Mirzaei, K 2021, 'The relationship between Dietary approaches to stop hypertension diet adherence and inflammatory factors and insulin resistance in overweight and obese women: A cross-sectional study', Diabetes Research and Clinical Practice, vol. 182, 109128. https://doi.org/10.1016/j.diabres.2021.109128

Taheri A, Mirzababaei A, Setayesh L, Yarizadeh H, Shiraseb F, Imani H et al. The relationship between Dietary approaches to stop hypertension diet adherence and inflammatory factors and insulin resistance in overweight and obese women: A cross-sectional study. Diabetes Research and Clinical Practice. 2021 Dec;182:109128. Epub 2021 Nov 14. doi: 10.1016/j.diabres.2021.109128

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note = "Funding Information: This study was supported by the Tehran University of Medical Sciences , and by grants from. Tehran University of Medical Sciences (Grants ID: 97-03-161-41155 and 99-3-212-51715 ). Funding Information: Thank you for the valuable cooperation of the officials of Tehran Health Centers in the implementation of this project, as well as for the cooperation of those who participated in data collection and nutrition evaluation. This study was supported by the Tehran University of Medical Sciences, and by grants from. Tehran University of Medical Sciences (Grants ID: 97-03-161-41155 and 99-3-212-51715). Ak.T. designed the study and collected the samples, A. M. and L. S entering FFQ data into NUTRITIONIST IV software, and wrote the paper, F. SH. revised the article, H. I. contributed to interpretation of the data and revised the article, Kh. M had full access to all of the data in the study and took responsibility for the integrity and accuracy of the data. All authors read and approved the final manuscript. Publisher Copyright: {\textcopyright} 2021",

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AU - Setayesh, Leila

AU - Yarizadeh, Habib

AU - Shiraseb, Farideh

AU - Imani, Hossein

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N2 - BACKGROUND: Although there is abundant evidence for an association between dietary pattern, weight, and other related factors, such as homeostatic model assessment for insulin resistance (HOMA-IR) and inflammatory markers; there is limited information pertaining to levels of plasminogen activator inhibitor-1 (PAI-1) and Monocyte Chemoattractant Protein -1 (MCP-1). Therefore, this study sought to examine the association between adherence to the dietary approaches to stop hypertension (DASH) diet and levels of inflammatory factors PAI-1, MCP-1, and HOMA-IR.METHODS: This cross-sectional study was performed on 305 obese and overweight women. The typical food intake of individuals was assessed using the 147 items semi-quantitative food frequency questionnaire (FFQ). Body components were measured for all participants. Insulin resistance was estimated by homeostasis model assessment (HOMA), and biochemical parameters were examined.RESULTS: No significant relationship was observed between the DASH diet and MCP-1 (P-trend = 0.70), PAI-1 (P-trend = 0.92), or HOMA-IR (P-trend = 0.08) in the crude model. However, there was a significant inverse relationship between the DASH diet and HOMA-IR (P-trend = 0.03) after adjusting for age, BMI, and physical activity.CONCLUSION: This study showed that higher adherence to DASH pattern is inversely correlated with HOMA-IR in overweight and obese women.

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The relationship between Dietary approaches to stop hypertension diet adherence and inflammatory factors and insulin resistance in overweight and obese women: A cross-sectional study

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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Cite this