BACKGROUND: Although there is abundant evidence for an association between dietary pattern, weight, and other related factors, such as homeostatic model assessment for insulin resistance (HOMA-IR) and inflammatory markers; there is limited information pertaining to levels of plasminogen activator inhibitor-1 (PAI-1) and Monocyte Chemoattractant Protein -1 (MCP-1). Therefore, this study sought to examine the association between adherence to the dietary approaches to stop hypertension (DASH) diet and levels of inflammatory factors PAI-1, MCP-1, and HOMA-IR.
METHODS: This cross-sectional study was performed on 305 obese and overweight women. The typical food intake of individuals was assessed using the 147 items semi-quantitative food frequency questionnaire (FFQ). Body components were measured for all participants. Insulin resistance was estimated by homeostasis model assessment (HOMA), and biochemical parameters were examined.
RESULTS: No significant relationship was observed between the DASH diet and MCP-1 (P-trend = 0.70), PAI-1 (P-trend = 0.92), or HOMA-IR (P-trend = 0.08) in the crude model. However, there was a significant inverse relationship between the DASH diet and HOMA-IR (P-trend = 0.03) after adjusting for age, BMI, and physical activity.
CONCLUSION: This study showed that higher adherence to DASH pattern is inversely correlated with HOMA-IR in overweight and obese women.
Bibliographical noteFunding Information:
This study was supported by the Tehran University of Medical Sciences , and by grants from. Tehran University of Medical Sciences (Grants ID: 97-03-161-41155 and 99-3-212-51715 ).
Thank you for the valuable cooperation of the officials of Tehran Health Centers in the implementation of this project, as well as for the cooperation of those who participated in data collection and nutrition evaluation. This study was supported by the Tehran University of Medical Sciences, and by grants from. Tehran University of Medical Sciences (Grants ID: 97-03-161-41155 and 99-3-212-51715). Ak.T. designed the study and collected the samples, A. M. and L. S entering FFQ data into NUTRITIONIST IV software, and wrote the paper, F. SH. revised the article, H. I. contributed to interpretation of the data and revised the article, Kh. M had full access to all of the data in the study and took responsibility for the integrity and accuracy of the data. All authors read and approved the final manuscript.
ASJC Scopus subject areas
- Internal Medicine
- Endocrinology, Diabetes and Metabolism