The regulatory roles of phosphatases in cancer

J. Stebbing; L. C. Lit; H. Zhang; Siobhan Darrington; O. Melaiu; B. Rudraraju; G. Giamas

doi:10.1038/onc.2013.80

The regulatory roles of phosphatases in cancer

J. Stebbing, L. C. Lit, H. Zhang, Siobhan Darrington, O. Melaiu, B. Rudraraju, G. Giamas

School of Life Sciences

Research output: Contribution to journal › Article › peer-review

55 Citations (Scopus)

31 Downloads (Pure)

Abstract

The relevance of potentially reversible post-translational modifications required for controlling cellular processes in cancer is one of the most thriving arenas of cellular and molecular biology. Any alteration in the balanced equilibrium between kinases and phosphatases may result in development and progression of various diseases, including different types of cancer, though phosphatases are relatively under-studied. Loss of phosphatases such as PTEN (phosphatase and tensin homologue deleted on chromosome 10), a known tumour suppressor, across tumour types lends credence to the development of phosphatidylinositol 3—kinase inhibitors alongside the use of phosphatase expression as a biomarker, though phase 3 trial data are lacking. In this review, we give an updated report on phosphatase dysregulation linked to organ-specific malignancies.

Original language	English
Pages (from-to)	939-953
Journal	Oncogene
Volume	33
Early online date	18 Mar 2013
DOIs	https://doi.org/10.1038/onc.2013.80
Publication status	Published - 20 Jan 2014

Keywords

cancer
phosphatases
solid tumours

Access to Document

10.1038/onc.2013.80

PHOSPHATASE REVIEW -200113Accepted author manuscript, 865 KB

Fingerprint Dive into the research topics of 'The regulatory roles of phosphatases in cancer'. Together they form a unique fingerprint.

Cite this

@article{db282810df8f4f4c8185da8c515ccfba,

title = "The regulatory roles of phosphatases in cancer",

abstract = "The relevance of potentially reversible post-translational modifications required for controlling cellular processes in cancer is one of the most thriving arenas of cellular and molecular biology. Any alteration in the balanced equilibrium between kinases and phosphatases may result in development and progression of various diseases, including different types of cancer, though phosphatases are relatively under-studied. Loss of phosphatases such as PTEN (phosphatase and tensin homologue deleted on chromosome 10), a known tumour suppressor, across tumour types lends credence to the development of phosphatidylinositol 3—kinase inhibitors alongside the use of phosphatase expression as a biomarker, though phase 3 trial data are lacking. In this review, we give an updated report on phosphatase dysregulation linked to organ-specific malignancies.",

keywords = "cancer, phosphatases, solid tumours",

author = "J. Stebbing and Lit, {L. C.} and H. Zhang and Siobhan Darrington and O. Melaiu and B. Rudraraju and G. Giamas",

year = "2014",

month = jan,

day = "20",

doi = "10.1038/onc.2013.80",

language = "English",

volume = "33",

pages = "939--953",

journal = "Oncogene",

issn = "0950-9232",

publisher = "Nature Publishing Group",

}

TY - JOUR

T1 - The regulatory roles of phosphatases in cancer

AU - Stebbing, J.

AU - Lit, L. C.

AU - Zhang, H.

AU - Darrington, Siobhan

AU - Melaiu, O.

AU - Rudraraju, B.

AU - Giamas, G.

PY - 2014/1/20

Y1 - 2014/1/20

N2 - The relevance of potentially reversible post-translational modifications required for controlling cellular processes in cancer is one of the most thriving arenas of cellular and molecular biology. Any alteration in the balanced equilibrium between kinases and phosphatases may result in development and progression of various diseases, including different types of cancer, though phosphatases are relatively under-studied. Loss of phosphatases such as PTEN (phosphatase and tensin homologue deleted on chromosome 10), a known tumour suppressor, across tumour types lends credence to the development of phosphatidylinositol 3—kinase inhibitors alongside the use of phosphatase expression as a biomarker, though phase 3 trial data are lacking. In this review, we give an updated report on phosphatase dysregulation linked to organ-specific malignancies.

AB - The relevance of potentially reversible post-translational modifications required for controlling cellular processes in cancer is one of the most thriving arenas of cellular and molecular biology. Any alteration in the balanced equilibrium between kinases and phosphatases may result in development and progression of various diseases, including different types of cancer, though phosphatases are relatively under-studied. Loss of phosphatases such as PTEN (phosphatase and tensin homologue deleted on chromosome 10), a known tumour suppressor, across tumour types lends credence to the development of phosphatidylinositol 3—kinase inhibitors alongside the use of phosphatase expression as a biomarker, though phase 3 trial data are lacking. In this review, we give an updated report on phosphatase dysregulation linked to organ-specific malignancies.

KW - cancer

KW - phosphatases

KW - solid tumours

U2 - 10.1038/onc.2013.80

DO - 10.1038/onc.2013.80

M3 - Article

VL - 33

SP - 939

EP - 953

JO - Oncogene

JF - Oncogene

SN - 0950-9232

ER -