The regulatory roles of phosphatases in cancer

J. Stebbing, L. C. Lit, H. Zhang, Siobhan Darrington, O. Melaiu, B. Rudraraju, G. Giamas

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Abstract

The relevance of potentially reversible post-translational modifications required for controlling cellular processes in cancer is one of the most thriving arenas of cellular and molecular biology. Any alteration in the balanced equilibrium between kinases and phosphatases may result in development and progression of various diseases, including different types of cancer, though phosphatases are relatively under-studied. Loss of phosphatases such as PTEN (phosphatase and tensin homologue deleted on chromosome 10), a known tumour suppressor, across tumour types lends credence to the development of phosphatidylinositol 3—kinase inhibitors alongside the use of phosphatase expression as a biomarker, though phase 3 trial data are lacking. In this review, we give an updated report on phosphatase dysregulation linked to organ-specific malignancies.
Original languageEnglish
Pages (from-to)939-953
JournalOncogene
Volume33
Early online date18 Mar 2013
DOIs
Publication statusPublished - 20 Jan 2014

Keywords

  • cancer
  • phosphatases
  • solid tumours

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    Stebbing, J., Lit, L. C., Zhang, H., Darrington, S., Melaiu, O., Rudraraju, B., & Giamas, G. (2014). The regulatory roles of phosphatases in cancer. Oncogene, 33, 939-953. https://doi.org/10.1038/onc.2013.80