The progressive role of acoustic cavitation for non-invasive therapies, contrast imaging and blood-tumor permeability enhancement

M. S. Aw, Larysa Paniwnyk, D. Losic

Research output: Contribution to journal › Review article

10 Citations (Scopus)

Abstract

Introduction: Drug delivery pertaining to acoustic cavitation generated from ultrasonic (US) irradiation is advantageous for devising smarter and more advanced therapeutics. The aim is to showcase microbubbles as drug carriers and robust theranostic for non-invasive therapies across diverse biomedical disciplines, highlighting recent technologies in this field for overcoming the blood-brain barrier (BBB) to treat cancers and neurological disorders. Areas covered: This article reviews work on the optimized tuning of ultrasonic parameters, sonoporation, transdermal and responsive drug delivery, acoustic cavitation in vasculature and oncology, contrast imaging for real-time magnification of cell-microbubble dynamics and biomolecular targeting. Scholarly literature was sought through database search on key terminology, latest topics, reputable experts and established journals over the last five years. Expert opinion: Cavitation offers immense promise in overcoming current diffusion and convection limitations for treating skull/brain/vascular/tissue injuries and ablating tumors to minimize chronic/acute effects. Since stable cavitation facilitates the restoration of US-opened BBB and the modulation of drug concentration, US equipment with programmable imaging modality and sensitivity are envisaged to create safer miniaturized devices for personalized care. Due to differing biomedical protocols with regard to specific medical conditions, quantitative and qualitative controls are mandatory before translation to real-life clinical applications can be accomplished.
Original languageEnglish
Pages (from-to)1383-1396
JournalExpert Opinion on Drug Delivery
Volume13
Issue number10
Early online date1 Jun 2016
DOIs
Publication statusPublished - 2016

Fingerprint

Acoustics
Ultrasonics
Permeability
Microbubbles
Blood-Brain Barrier
Cerebrovascular Trauma
Neoplasms
Pharmaceutical Preparations
Equipment and Supplies
Convection
Drug Carriers
Expert Testimony
Therapeutics
Nervous System Diseases
Terminology
Skull
Databases
Technology

Bibliographical note

The full text is currently unavailable on the repository.

Keywords

  • Acoustic cavitation
  • blood-brain barrier
  • cancer
  • contrasts imaging
  • drug delivery
  • non-invasiveness
  • sonoporation

Cite this

The progressive role of acoustic cavitation for non-invasive therapies, contrast imaging and blood-tumor permeability enhancement. / Aw, M. S.; Paniwnyk, Larysa; Losic, D.

In: Expert Opinion on Drug Delivery, Vol. 13, No. 10, 2016, p. 1383-1396.

Research output: Contribution to journal › Review article

Aw, MS, Paniwnyk, L & Losic, D 2016, 'The progressive role of acoustic cavitation for non-invasive therapies, contrast imaging and blood-tumor permeability enhancement' Expert Opinion on Drug Delivery, vol. 13, no. 10, pp. 1383-1396. https://doi.org/10.1080/17425247.2016.1192123
Aw MS, Paniwnyk L, Losic D. The progressive role of acoustic cavitation for non-invasive therapies, contrast imaging and blood-tumor permeability enhancement. Expert Opinion on Drug Delivery. 2016;13(10):1383-1396. https://doi.org/10.1080/17425247.2016.1192123
Aw, M. S. ; Paniwnyk, Larysa ; Losic, D. / The progressive role of acoustic cavitation for non-invasive therapies, contrast imaging and blood-tumor permeability enhancement. In: Expert Opinion on Drug Delivery. 2016 ; Vol. 13, No. 10. pp. 1383-1396.
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