The Persistence of Self-injurious and Aggressive Behavior in Males with Fragile X Syndrome Over 8 Years: A Longitudinal Study of Prevalence and Predictive Risk Markers

Hayley Crawford; Efthalia Karakatsani; Gursharan Singla; Chris Oliver

doi:10.1007/s10803-019-04002-3

The Persistence of Self-injurious and Aggressive Behavior in Males with Fragile X Syndrome Over 8 Years: A Longitudinal Study of Prevalence and Predictive Risk Markers

Hayley Crawford
, Efthalia Karakatsani
, Gursharan Singla
, Chris Oliver

University of Wolverhampton
University of Birmingham

Research output: Contribution to journal › Article › peer-review

32 Citations (Scopus)

120 Downloads (Pure)

Abstract

Self-injurious and aggressive behaviors are common in fragile X syndrome (FXS). However, little is known about the persistence of these behaviors and associated risk markers. We established the prevalence and persistence of self-injurious and aggressive behaviors over eight years in males with FXS, and associations with risk markers. Results showed 77% and 69% persistence rates for self-injurious and aggressive behavior, respectively. Baseline levels of repetitive behavior predicted persistent self-injurious behavior. Chronological age, impulsivity and overactivity were associated with persistent aggressive behavior but only impulsivity predicted persistence. This is the first study to document the persistence of self-injurious and aggressive behavior in FXS over the medium to long term and to identify behavioral risk markers that might facilitate targeted early intervention.

Original language	English
Pages (from-to)	2913-2922
Number of pages	10
Journal	Journal of Autism and Developmental Disorders
Volume	49
Issue number	7
Early online date	24 Apr 2019
DOIs	https://doi.org/10.1007/s10803-019-04002-3
Publication status	Published - 15 Jul 2019

Bibliographical note

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

Keywords

Aggression
Autism
Challenging behavior
Early intervention
Fragile X syndrome
Impulsivity
Repetitive behavior
Risk markers
Self-injurious behavior

ASJC Scopus subject areas

Developmental and Educational Psychology

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10.1007/s10803-019-04002-3Licence: CC BY

PublishedFinal published version, 966 KBLicence: CC BY

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The Persistence of Self-injurious and Aggressive Behavior in Males with Fragile X Syndrome Over 8 Years: A Longitudinal Study of Prevalence and Predictive Risk Markers. / Crawford, Hayley; Karakatsani, Efthalia; Singla, Gursharan et al.
In: Journal of Autism and Developmental Disorders, Vol. 49, No. 7, 15.07.2019, p. 2913-2922.

Research output: Contribution to journal › Article › peer-review

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abstract = "Self-injurious and aggressive behaviors are common in fragile X syndrome (FXS). However, little is known about the persistence of these behaviors and associated risk markers. We established the prevalence and persistence of self-injurious and aggressive behaviors over eight years in males with FXS, and associations with risk markers. Results showed 77\% and 69\% persistence rates for self-injurious and aggressive behavior, respectively. Baseline levels of repetitive behavior predicted persistent self-injurious behavior. Chronological age, impulsivity and overactivity were associated with persistent aggressive behavior but only impulsivity predicted persistence. This is the first study to document the persistence of self-injurious and aggressive behavior in FXS over the medium to long term and to identify behavioral risk markers that might facilitate targeted early intervention.",

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The Persistence of Self-injurious and Aggressive Behavior in Males with Fragile X Syndrome Over 8 Years: A Longitudinal Study of Prevalence and Predictive Risk Markers

Abstract

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Keywords

ASJC Scopus subject areas

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