The nuclear factor kappa B signaling pathway: integrating metabolism with inflammation

Laura Tornatore, Anil K. Thotakura, Jason Bennett, Marta Moretti, Guido Franzoso

Research output: Contribution to journalArticle

213 Citations (Scopus)

Abstract

Nuclear factor kappa B (NF-κB) transcription factors are evolutionarily conserved, coordinating regulators of immune and inflammatory responses. They also play a pivotal role in oncogenesis and metabolic disorders. Several studies during the past two decades have highlighted the key role of the IKK/NF-κB pathway in the induction and maintenance of the state of inflammation that underlies metabolic diseases such as obesity and type 2 diabetes. Recent reports, however, reveal an even more intimate connection between NF-κB and metabolism. These studies demonstrate that NF-κB regulates energy homeostasis via direct engagement of the cellular networks governing glycolysis and respiration, with profound implications beyond metabolic diseases, including cancer, ageing and anticancer therapy. In this review, we discuss these emerging bioenergetic functions of NF-κB and their significance to oncogenesis.
Original languageEnglish
Pages (from-to)557-566
Number of pages10
JournalTrends in Cell Biology
Volume22
Issue number11
Early online date18 Sep 2012
DOIs
Publication statusPublished - 1 Nov 2012

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NF-kappa B
Inflammation
Metabolic Diseases
Carcinogenesis
Glycolysis
Type 2 Diabetes Mellitus
Energy Metabolism
Respiration
Homeostasis
Transcription Factors
Obesity
Maintenance
Neoplasms

Keywords

  • NF-κB
  • metabolism
  • mitochondria
  • respiration
  • glycolysis
  • cancer

Cite this

The nuclear factor kappa B signaling pathway: integrating metabolism with inflammation. / Tornatore, Laura ; Thotakura, Anil K. ; Bennett, Jason; Moretti, Marta; Franzoso, Guido .

In: Trends in Cell Biology, Vol. 22, No. 11, 01.11.2012, p. 557-566.

Research output: Contribution to journalArticle

Tornatore, Laura ; Thotakura, Anil K. ; Bennett, Jason ; Moretti, Marta ; Franzoso, Guido . / The nuclear factor kappa B signaling pathway: integrating metabolism with inflammation. In: Trends in Cell Biology. 2012 ; Vol. 22, No. 11. pp. 557-566.
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