The New Frontiers in Bone Tissue Engineering: Functionalized Biomimetic Surfaces beyond Morphogens and Stem Cells

Ugo Ripamonti, Laura Roden

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The angiogenic induction in mesenchymal condensations is noteworthy and correlates with the alkaline phosphatase staining. High-power views indicate the migration of mesenchymal stem cells from the angiogenic compartment of the invading mesenchymal condensations to the osteogenic compartment of the differentiating osteogenic cells at the hydroxyapatite interface. Osteoclastic activity re-patterning the surface micro-geometry of the implanted macroporous bioreactors is the key factor resulting in the spontaneous and/or intrinsic induction of bone formation. The critical role of the concavity spontaneously initiating the induction of bone formation was confirmed by intramuscular rectus abdominis implantation of sintered crystalline hydroxyapatites with concavities of specific dimensions on both planar surfaces of the sintered constructs. The central question in developmental biology and thus tissue engineering and regenerative medicine is the molecular basis of pattern formation.
Original languageEnglish
Title of host publicationThe Geometric Induction of Bone Formation
EditorsUgo Ripamonti
Place of PublicationBoca Raton
PublisherCRC Press, Taylor & Francis Group
Chapter1
Pages1-20
Number of pages20
Edition1
ISBN (Electronic)9780429203299
ISBN (Print)9780367195786
DOIs
Publication statusPublished - 23 Dec 2020

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