The mediatory effect of inflammatory markers on the association between a body shape index and body roundness index with cardiometabolic risk factor in overweight and obese women: a cross-sectional study

Atieh Mirzababaei; Faezeh Abaj; Darya Khosravinia; Moloud Ghorbani; Neda Valisoltani; Cain C T Clark; Mina Radmehr; Khadijeh Mirzaei

doi:10.3389/fnut.2023.1178829

The mediatory effect of inflammatory markers on the association between a body shape index and body roundness index with cardiometabolic risk factor in overweight and obese women: a cross-sectional study

Atieh Mirzababaei, Faezeh Abaj, Darya Khosravinia, Moloud Ghorbani, Neda Valisoltani, Cain C T Clark, Mina Radmehr, Khadijeh Mirzaei

Centre for Healthcare and Communities

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Abstract

BACKGROUND: Obesity affects body composition and anthropometric measurements. A Body Shape Index (ABSI) and Body Roundness Index (BRI) are reportedly associated with an increased risk of cardiovascular disease. However, the relationship between ABSI, BRI, cardiometabolic factors, and inflammatory elements is not well-elucidated. Therefore, this study sought to examine the mediatory effect of inflammatory markers on the association between ABSI and BRI with cardiometabolic risk factors in overweight and obese women.

METHODS: This cross-sectional study was performed on 394 obese and overweight women. The typical food intake of individuals was assessed using a 147-item semi-quantitative Food Frequency Questionnaire (FFQ). Body composition was measured by bioelectrical impedance analysis (BIA). Biochemical parameters, such as inflammatory markers and anthropometric components, were also assessed. For each participant, all measurements were carried out on the same day.

RESULT: There was a significant positive association between ABSI and AC and CRI.I in subjects with higher ABSI scores before and after adjustment ( P < 0.05). In addition, there was a significant positive association between BRI and FBS, TC, TG, AIP, AC, CRI.I, CRI.II, and TyG in participants with higher BRI scores before and after adjustment ( P < 0.05). We found that hs-CRP, PAI-1, MCP-1, TGF-β, and Galectin-3 were mediators of these relationships ( P < 0.05).

CONCLUSION: Inflammation can play an important role in the relationship between body shape indices and cardiometabolic risk factors among overweight and obese women.

Original language	English
Article number	1178829
Number of pages	11
Journal	Frontiers in Nutrition
Volume	10
DOIs	https://doi.org/10.3389/fnut.2023.1178829
Publication status	Published - 9 Jun 2023

Bibliographical note

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is
permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

Funder

This study was supported by the Tehran University of Medical Sciences (Grant No: 96-01-161-34479/95-04-161-33893).

Keywords

a body shape index
body roundness index
inflammation markers
obesity
cardiometabolic

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Mirzababaei, A., Abaj, F., Khosravinia, D., Ghorbani, M., Valisoltani, N., Clark, C. C. T., Radmehr, M., & Mirzaei, K. (2023). The mediatory effect of inflammatory markers on the association between a body shape index and body roundness index with cardiometabolic risk factor in overweight and obese women: a cross-sectional study. Frontiers in Nutrition, 10, Article 1178829. https://doi.org/10.3389/fnut.2023.1178829

The mediatory effect of inflammatory markers on the association between a body shape index and body roundness index with cardiometabolic risk factor in overweight and obese women: a cross-sectional study. / Mirzababaei, Atieh; Abaj, Faezeh; Khosravinia, Darya et al.
In: Frontiers in Nutrition, Vol. 10, 1178829, 09.06.2023.

Research output: Contribution to journal › Article › peer-review

Mirzababaei, A, Abaj, F, Khosravinia, D, Ghorbani, M, Valisoltani, N, Clark, CCT, Radmehr, M & Mirzaei, K 2023, 'The mediatory effect of inflammatory markers on the association between a body shape index and body roundness index with cardiometabolic risk factor in overweight and obese women: a cross-sectional study', Frontiers in Nutrition, vol. 10, 1178829. https://doi.org/10.3389/fnut.2023.1178829

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abstract = "BACKGROUND: Obesity affects body composition and anthropometric measurements. A Body Shape Index (ABSI) and Body Roundness Index (BRI) are reportedly associated with an increased risk of cardiovascular disease. However, the relationship between ABSI, BRI, cardiometabolic factors, and inflammatory elements is not well-elucidated. Therefore, this study sought to examine the mediatory effect of inflammatory markers on the association between ABSI and BRI with cardiometabolic risk factors in overweight and obese women.METHODS: This cross-sectional study was performed on 394 obese and overweight women. The typical food intake of individuals was assessed using a 147-item semi-quantitative Food Frequency Questionnaire (FFQ). Body composition was measured by bioelectrical impedance analysis (BIA). Biochemical parameters, such as inflammatory markers and anthropometric components, were also assessed. For each participant, all measurements were carried out on the same day.RESULT: There was a significant positive association between ABSI and AC and CRI.I in subjects with higher ABSI scores before and after adjustment ( P < 0.05). In addition, there was a significant positive association between BRI and FBS, TC, TG, AIP, AC, CRI.I, CRI.II, and TyG in participants with higher BRI scores before and after adjustment ( P < 0.05). We found that hs-CRP, PAI-1, MCP-1, TGF-β, and Galectin-3 were mediators of these relationships ( P < 0.05). CONCLUSION: Inflammation can play an important role in the relationship between body shape indices and cardiometabolic risk factors among overweight and obese women.",

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author = "Atieh Mirzababaei and Faezeh Abaj and Darya Khosravinia and Moloud Ghorbani and Neda Valisoltani and Clark, {Cain C T} and Mina Radmehr and Khadijeh Mirzaei",

note = "This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.",

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T2 - a cross-sectional study

AU - Mirzababaei, Atieh

AU - Abaj, Faezeh

AU - Khosravinia, Darya

AU - Ghorbani, Moloud

AU - Valisoltani, Neda

AU - Clark, Cain C T

AU - Radmehr, Mina

AU - Mirzaei, Khadijeh

N1 - This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PY - 2023/6/9

Y1 - 2023/6/9

N2 - BACKGROUND: Obesity affects body composition and anthropometric measurements. A Body Shape Index (ABSI) and Body Roundness Index (BRI) are reportedly associated with an increased risk of cardiovascular disease. However, the relationship between ABSI, BRI, cardiometabolic factors, and inflammatory elements is not well-elucidated. Therefore, this study sought to examine the mediatory effect of inflammatory markers on the association between ABSI and BRI with cardiometabolic risk factors in overweight and obese women.METHODS: This cross-sectional study was performed on 394 obese and overweight women. The typical food intake of individuals was assessed using a 147-item semi-quantitative Food Frequency Questionnaire (FFQ). Body composition was measured by bioelectrical impedance analysis (BIA). Biochemical parameters, such as inflammatory markers and anthropometric components, were also assessed. For each participant, all measurements were carried out on the same day.RESULT: There was a significant positive association between ABSI and AC and CRI.I in subjects with higher ABSI scores before and after adjustment ( P < 0.05). In addition, there was a significant positive association between BRI and FBS, TC, TG, AIP, AC, CRI.I, CRI.II, and TyG in participants with higher BRI scores before and after adjustment ( P < 0.05). We found that hs-CRP, PAI-1, MCP-1, TGF-β, and Galectin-3 were mediators of these relationships ( P < 0.05). CONCLUSION: Inflammation can play an important role in the relationship between body shape indices and cardiometabolic risk factors among overweight and obese women.

AB - BACKGROUND: Obesity affects body composition and anthropometric measurements. A Body Shape Index (ABSI) and Body Roundness Index (BRI) are reportedly associated with an increased risk of cardiovascular disease. However, the relationship between ABSI, BRI, cardiometabolic factors, and inflammatory elements is not well-elucidated. Therefore, this study sought to examine the mediatory effect of inflammatory markers on the association between ABSI and BRI with cardiometabolic risk factors in overweight and obese women.METHODS: This cross-sectional study was performed on 394 obese and overweight women. The typical food intake of individuals was assessed using a 147-item semi-quantitative Food Frequency Questionnaire (FFQ). Body composition was measured by bioelectrical impedance analysis (BIA). Biochemical parameters, such as inflammatory markers and anthropometric components, were also assessed. For each participant, all measurements were carried out on the same day.RESULT: There was a significant positive association between ABSI and AC and CRI.I in subjects with higher ABSI scores before and after adjustment ( P < 0.05). In addition, there was a significant positive association between BRI and FBS, TC, TG, AIP, AC, CRI.I, CRI.II, and TyG in participants with higher BRI scores before and after adjustment ( P < 0.05). We found that hs-CRP, PAI-1, MCP-1, TGF-β, and Galectin-3 were mediators of these relationships ( P < 0.05). CONCLUSION: Inflammation can play an important role in the relationship between body shape indices and cardiometabolic risk factors among overweight and obese women.

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KW - cardiometabolic

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The mediatory effect of inflammatory markers on the association between a body shape index and body roundness index with cardiometabolic risk factor in overweight and obese women: a cross-sectional study

Abstract

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Keywords

UN SDGs

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