The interaction of aging with serum 25(OH)D and 1,25(OH)2 D status on muscle strength

Samira Davarzani, Kurosh Djafarian, Cain C T Clark, Nadia Babaei, Parivash Ghorbaninejad, Mojdeh Ebaditabar, Sakineh Shab-Bidar

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    Background: To investigate the combination relationship of age with serum 25-hydroxyvitamin D (25(OH) D) and 1,25-(OH)2D3 levels on muscle strength. Methods: We performed a cross-sectional study on 270 subjects containing 115 men and 155 women. Serum concentration of 25(OH) D and 1,25-(OH)2D3 were assessed. Hand grip strength (HGS) was measured using a digital dynamometer. Results: There was no significant difference in mean of HGS among tertiles of 25(OH)D (P =.350) and 1,25(OH) 2 D (P =.467) before and after controlling for potential confounding factors. A significant difference in HGS was found between age categories in both crude (P <.001) and adjusted models (P =.018), where mean grip strength increased in the three first age categories, but decreased in the last group (48-69 years old). There was also a significant interaction between age and 25(OH) D (P =.049) and 1,25-(OH)2D3 (P =.047) on HGS, in which the combination effect increased the mean of muscle strength up to middle age after adjusting for confounders. Conclusions: Serum 25(OH)D and 1,25(OH) 2 D were not related to muscle strength. However, age, and combination of age with both 25(OH)D and 1,25(OH) 2 D, significantly resulted in improving in muscle strength up to middle age.

    Original languageEnglish
    Article numbere14510
    JournalInternational Journal of Clinical Practice
    Issue number10
    Early online date12 Jun 2021
    Publication statusPublished - Oct 2021

    Bibliographical note

    This is the peer reviewed version of the following article: Davarzani, S, Djafarian, K, Clark, CCT, Babaei, N, Ghorbaninejad, P, Ebaditabar, M & Shab-Bidar, S 2021, 'The interaction of aging with serum 25(OH)D and 1,25(OH)2 D status on muscle strength', International Journal of Clinical Practice, vol. 75, no. 10, e14510, which has been published in final form at This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.


    This manuscript has been granted by Tehran University of Medical Sciences (Grant No: 40192)


    • 1,25-(OH)2D3
    • 25-hydroxyvitamin D
    • muscle strength
    • vitamin D

    ASJC Scopus subject areas

    • Medicine(all)


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