The interaction of aging with serum 25(OH)D and 1,25(OH)2 D status on muscle strength

Samira Davarzani, Kurosh Djafarian, Cain C T Clark, Nadia Babaei, Parivash Ghorbaninejad, Mojdeh Ebaditabar, Sakineh Shab-Bidar

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    Abstract

    Background: To investigate the combination relationship of age with serum 25-hydroxyvitamin D (25(OH) D) and 1,25-(OH)2D3 levels on muscle strength. Methods: We performed a cross-sectional study on 270 subjects containing 115 men and 155 women. Serum concentration of 25(OH) D and 1,25-(OH)2D3 were assessed. Hand grip strength (HGS) was measured using a digital dynamometer. Results: There was no significant difference in mean of HGS among tertiles of 25(OH)D (P =.350) and 1,25(OH) 2 D (P =.467) before and after controlling for potential confounding factors. A significant difference in HGS was found between age categories in both crude (P <.001) and adjusted models (P =.018), where mean grip strength increased in the three first age categories, but decreased in the last group (48-69 years old). There was also a significant interaction between age and 25(OH) D (P =.049) and 1,25-(OH)2D3 (P =.047) on HGS, in which the combination effect increased the mean of muscle strength up to middle age after adjusting for confounders. Conclusions: Serum 25(OH)D and 1,25(OH) 2 D were not related to muscle strength. However, age, and combination of age with both 25(OH)D and 1,25(OH) 2 D, significantly resulted in improving in muscle strength up to middle age.

    Original languageEnglish
    Article numbere14510
    JournalInternational Journal of Clinical Practice
    Volume75
    Issue number10
    Early online date12 Jun 2021
    DOIs
    Publication statusPublished - Oct 2021

    Bibliographical note

    This is the peer reviewed version of the following article: Davarzani, S, Djafarian, K, Clark, CCT, Babaei, N, Ghorbaninejad, P, Ebaditabar, M & Shab-Bidar, S 2021, 'The interaction of aging with serum 25(OH)D and 1,25(OH)2 D status on muscle strength', International Journal of Clinical Practice, vol. 75, no. 10, e14510, which has been published in final form at https://dx.doi.org/10.1111/ijcp.14510. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.

    Funder

    This manuscript has been granted by Tehran University of Medical Sciences (Grant No: 40192)

    Keywords

    • 1,25-(OH)2D3
    • 25-hydroxyvitamin D
    • muscle strength
    • vitamin D

    ASJC Scopus subject areas

    • Medicine(all)

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