The interaction of aging with serum 25(OH)D and 1,25(OH)2 D status on muscle strength

Samira Davarzani; Kurosh Djafarian; Cain C T Clark; Nadia Babaei; Parivash Ghorbaninejad; Mojdeh Ebaditabar; Sakineh Shab-Bidar

doi:10.1111/ijcp.14510

The interaction of aging with serum 25(OH)D and 1,25(OH)2 D status on muscle strength

Samira Davarzani, Kurosh Djafarian, Cain C T Clark, Nadia Babaei, Parivash Ghorbaninejad, Mojdeh Ebaditabar, Sakineh Shab-Bidar

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Abstract

Background: To investigate the combination relationship of age with serum 25-hydroxyvitamin D (25(OH) D) and 1,25-(OH)2D3 levels on muscle strength. Methods: We performed a cross-sectional study on 270 subjects containing 115 men and 155 women. Serum concentration of 25(OH) D and 1,25-(OH)2D3 were assessed. Hand grip strength (HGS) was measured using a digital dynamometer. Results: There was no significant difference in mean of HGS among tertiles of 25(OH)D (P =.350) and 1,25(OH) ₂ D (P =.467) before and after controlling for potential confounding factors. A significant difference in HGS was found between age categories in both crude (P <.001) and adjusted models (P =.018), where mean grip strength increased in the three first age categories, but decreased in the last group (48-69 years old). There was also a significant interaction between age and 25(OH) D (P =.049) and 1,25-(OH)2D3 (P =.047) on HGS, in which the combination effect increased the mean of muscle strength up to middle age after adjusting for confounders. Conclusions: Serum 25(OH)D and 1,25(OH) ₂ D were not related to muscle strength. However, age, and combination of age with both 25(OH)D and 1,25(OH) ₂ D, significantly resulted in improving in muscle strength up to middle age.

Original language	English
Article number	e14510
Journal	International Journal of Clinical Practice
Volume	75
Issue number	10
Early online date	12 Jun 2021
DOIs	https://doi.org/10.1111/ijcp.14510
Publication status	Published - Oct 2021

Bibliographical note

This is the peer reviewed version of the following article: Davarzani, S, Djafarian, K, Clark, CCT, Babaei, N, Ghorbaninejad, P, Ebaditabar, M & Shab-Bidar, S 2021, 'The interaction of aging with serum 25(OH)D and 1,25(OH)2 D status on muscle strength', International Journal of Clinical Practice, vol. 75, no. 10, e14510, which has been published in final form at https://dx.doi.org/10.1111/ijcp.14510. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.

Funder

This manuscript has been granted by Tehran University of Medical Sciences (Grant No: 40192)

Keywords

1,25-(OH)2D3
25-hydroxyvitamin D
muscle strength
vitamin D

ASJC Scopus subject areas

General Medicine

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10.1111/ijcp.14510

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title = "The interaction of aging with serum 25(OH)D and 1,25(OH)2 D status on muscle strength",

abstract = "Background: To investigate the combination relationship of age with serum 25-hydroxyvitamin D (25(OH) D) and 1,25-(OH)2D3 levels on muscle strength. Methods: We performed a cross-sectional study on 270 subjects containing 115 men and 155 women. Serum concentration of 25(OH) D and 1,25-(OH)2D3 were assessed. Hand grip strength (HGS) was measured using a digital dynamometer. Results: There was no significant difference in mean of HGS among tertiles of 25(OH)D (P =.350) and 1,25(OH) 2 D (P =.467) before and after controlling for potential confounding factors. A significant difference in HGS was found between age categories in both crude (P <.001) and adjusted models (P =.018), where mean grip strength increased in the three first age categories, but decreased in the last group (48-69 years old). There was also a significant interaction between age and 25(OH) D (P =.049) and 1,25-(OH)2D3 (P =.047) on HGS, in which the combination effect increased the mean of muscle strength up to middle age after adjusting for confounders. Conclusions: Serum 25(OH)D and 1,25(OH) 2 D were not related to muscle strength. However, age, and combination of age with both 25(OH)D and 1,25(OH) 2 D, significantly resulted in improving in muscle strength up to middle age. ",

keywords = "1,25-(OH)2D3, 25-hydroxyvitamin D, muscle strength, vitamin D",

author = "Samira Davarzani and Kurosh Djafarian and Clark, {Cain C T} and Nadia Babaei and Parivash Ghorbaninejad and Mojdeh Ebaditabar and Sakineh Shab-Bidar",

note = "This is the peer reviewed version of the following article: Davarzani, S, Djafarian, K, Clark, CCT, Babaei, N, Ghorbaninejad, P, Ebaditabar, M & Shab-Bidar, S 2021, 'The interaction of aging with serum 25(OH)D and 1,25(OH)2 D status on muscle strength', International Journal of Clinical Practice, vol. 75, no. 10, e14510, which has been published in final form at https://dx.doi.org/10.1111/ijcp.14510. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.",

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AU - Davarzani, Samira

AU - Djafarian, Kurosh

AU - Clark, Cain C T

AU - Babaei, Nadia

AU - Ghorbaninejad, Parivash

AU - Ebaditabar, Mojdeh

AU - Shab-Bidar, Sakineh

N1 - This is the peer reviewed version of the following article: Davarzani, S, Djafarian, K, Clark, CCT, Babaei, N, Ghorbaninejad, P, Ebaditabar, M & Shab-Bidar, S 2021, 'The interaction of aging with serum 25(OH)D and 1,25(OH)2 D status on muscle strength', International Journal of Clinical Practice, vol. 75, no. 10, e14510, which has been published in final form at https://dx.doi.org/10.1111/ijcp.14510. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.

PY - 2021/10

Y1 - 2021/10

N2 - Background: To investigate the combination relationship of age with serum 25-hydroxyvitamin D (25(OH) D) and 1,25-(OH)2D3 levels on muscle strength. Methods: We performed a cross-sectional study on 270 subjects containing 115 men and 155 women. Serum concentration of 25(OH) D and 1,25-(OH)2D3 were assessed. Hand grip strength (HGS) was measured using a digital dynamometer. Results: There was no significant difference in mean of HGS among tertiles of 25(OH)D (P =.350) and 1,25(OH) 2 D (P =.467) before and after controlling for potential confounding factors. A significant difference in HGS was found between age categories in both crude (P <.001) and adjusted models (P =.018), where mean grip strength increased in the three first age categories, but decreased in the last group (48-69 years old). There was also a significant interaction between age and 25(OH) D (P =.049) and 1,25-(OH)2D3 (P =.047) on HGS, in which the combination effect increased the mean of muscle strength up to middle age after adjusting for confounders. Conclusions: Serum 25(OH)D and 1,25(OH) 2 D were not related to muscle strength. However, age, and combination of age with both 25(OH)D and 1,25(OH) 2 D, significantly resulted in improving in muscle strength up to middle age.

AB - Background: To investigate the combination relationship of age with serum 25-hydroxyvitamin D (25(OH) D) and 1,25-(OH)2D3 levels on muscle strength. Methods: We performed a cross-sectional study on 270 subjects containing 115 men and 155 women. Serum concentration of 25(OH) D and 1,25-(OH)2D3 were assessed. Hand grip strength (HGS) was measured using a digital dynamometer. Results: There was no significant difference in mean of HGS among tertiles of 25(OH)D (P =.350) and 1,25(OH) 2 D (P =.467) before and after controlling for potential confounding factors. A significant difference in HGS was found between age categories in both crude (P <.001) and adjusted models (P =.018), where mean grip strength increased in the three first age categories, but decreased in the last group (48-69 years old). There was also a significant interaction between age and 25(OH) D (P =.049) and 1,25-(OH)2D3 (P =.047) on HGS, in which the combination effect increased the mean of muscle strength up to middle age after adjusting for confounders. Conclusions: Serum 25(OH)D and 1,25(OH) 2 D were not related to muscle strength. However, age, and combination of age with both 25(OH)D and 1,25(OH) 2 D, significantly resulted in improving in muscle strength up to middle age.

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The interaction of aging with serum 25(OH)D and 1,25(OH)2 D status on muscle strength

Abstract

Bibliographical note

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Keywords

ASJC Scopus subject areas

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