The influence of green coffee bean extract supplementation on blood glucose levels: A systematic review and dose-response meta-analysis of randomized controlled trials

Yan Chen, Ying Zhao, Yanjun Wang, Ali Nazary-Vannani, Cain C T Clark, Melahat Sedanur Macit, Vahid Khani, Yong Zhang

Research output: Contribution to journalReview article

Abstract

Studies regarding the influence of green coffee extract (GCE) on blood glucose levels are conflicting. Thus, we sought to conduct a meta-analysis and systematic review of all available randomized controlled trials (RCTs) to quantify the effects of GCE and CGA intervention on blood glucose and insulin levels. We performed systematic online searches in Scopus, Web of science, and PubMed databases, from inception to July 2019. Data were combined analyzed using a random effects model (Der Simonian-Laird method) and reported as weighted mean differences (WMD). Ten trials reported the influences of GCE on FBS and insulin and were subsequently entered into the meta-analysis. Combined results highlighted that FBS was significantly altered after GCE consumption (WMD: -1.791 mg/dl, 95% CI -3.404, -0.177), with no significant heterogeneity among the studies (I2 = 35.0%, p = .128). However, overall results demonstrated that GCE administration did not result in any significant alteration in insulin levels (WMD: -0.925 μU/ml, 95% CI:-1.915, 0.064), with significant heterogeneity found across studies (I2 = 87.9%). In sub-group analysis, insulin levels were significantly reduced when GCE was supplemented in dosages of ≥400 mg/day (WMD:-1.942 mg/dl, 95% CI:-1.184, -0.975; I2 = 0.0%). The results of present study support the use of GCE for the enhancement of blood glucose, while subgroup analysis highlighted significant improvements in insulin levels when GCE is supplemented in doses ≥400 mg/day.

Original languageEnglish
Pages (from-to)2159-2169
Number of pages11
JournalPhytotherapy Research
Volume34
Issue number9
Early online date11 Mar 2020
DOIs
Publication statusPublished - 1 Sep 2020

Bibliographical note

This is the peer reviewed version of the following article: Chen, Y, Zhao, Y, Wang, Y, Nazary-Vannani, A, Clark, CCT, Sedanur Macit, M, Khani, V & Zhang, Y 2020, 'The influence of green coffee bean extract supplementation on blood glucose levels: A systematic review and dose-response meta-analysis of randomized controlled trials', Phytotherapy Research, vol. 34, no. 9, pp. 2159-2169 which has been published in final form at https://onlinelibrary.wiley.com/doi/10.1002/ptr.6667. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.

Keywords

  • FBS
  • blood glucose
  • green coffee
  • insulin

ASJC Scopus subject areas

  • Pharmacology

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