The importance of parameter choice in modelling dynamics of the eye lens

Kehao Wang; Demetrios T. Venetsanos; Jian Wang; Andy T. Augousti; Barbara K. Pierscionek

doi:10.1038/s41598-017-16854-9

The importance of parameter choice in modelling dynamics of the eye lens

Kehao Wang, Demetrios T. Venetsanos, Jian Wang, Andy T. Augousti, Barbara K. Pierscionek

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

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Abstract

The lens provides refractive power to the eye and is capable of altering ocular focus in response to visual demand. This capacity diminishes with age. Current biomedical technologies, which seek to design an implant lens capable of replicating the function of the biological lens, are unable as yet to provide such an implant with the requisite optical quality or ability to change the focussing power of the eye. This is because the mechanism of altering focus, termed accommodation, is not fully understood and seemingly conflicting theories require experimental support which is difficult to obtain from the living eye. This investigation presents finite element models of the eye lens based on data from human lenses aged 16 and 35 years that consider the influence of various modelling parameters, including material properties, a wide range of angles of force application and capsular thickness. Results from axisymmetric models show that the anterior and posterior zonules may have a greater impact on shape change than the equatorial zonule and that choice of capsular thickness values can influence the results from modelled simulations.

Original language	English
Article number	16688
Journal	Scientific Reports
Volume	7
Issue number	1
Early online date	30 Nov 2017
DOIs	https://doi.org/10.1038/s41598-017-16854-9
Publication status	Published - 2017
Externally published	Yes

Bibliographical note

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. Te images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The importance of parameter choice in modelling dynamics of the eye lens

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