The Impact of a 24-h Ultra-Marathon on Salivary Antimicrobial Protein Responses

Samantha K. Gill, A.M. Teixeira, Fatima Rosado, Joanne Hankey, Alice Wright, Slawomir Marczak, Andrew Duncan Murray, Ricardo Jose Soares Costa

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23 Citations (Scopus)


Depressed oral respiratory mucosal immunity and increased incidence of upper respiratory symptoms are commonly reported after bouts of prolonged exercise. The current study observed the impact of a 24-h continuous overnight ultra-marathon competition (distance range: 122–208 km; ambient temperature range: 0–20°C) on salivary antimicrobial protein responses and incidence of upper respiratory symptoms. Body mass, unstimulated saliva and venous blood samples were taken from ultra-endurance runners (n=25) and controls (n=17), before and immediately after competition. Upper respiratory symptoms were assessed during and until 4-weeks after event completion. Samples were analyzed for salivary IgA, lysozyme, α-amylase and cortisol in addition to plasma osmolality. Decreased saliva flow rate (p
Original languageEnglish
Pages (from-to)966-971
JournalInternational Journal of Sports Medicine
Issue number11
Early online date2 Jun 2014
Publication statusPublished - Oct 2014

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  • α-amylase
  • immunoglobulin A
  • lysozyme
  • running
  • upper respiratory
  • water


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