The health effects of medical nutrition therapy by dietitians in patients with diabetes: A systematic review and meta-analysis

Jalaledin Mirzay Razaz, Jamal Rahmani, Hamed Kord Varkaneh, Jacqueline Thompson, Cain Clark, hebatullah Abdulazeem

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    29 Citations (Scopus)
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    Aims: Intensive lifestyle, dietary interventions and patient education have been recommended as key milestones in to facilitate the management of Diabetes and contain the growing incidence. We performed a systematic review and meta-analysis to assess the health benefits of medical nutrition therapy among patients with diabetes. Design: A systematic search was performed in MEDLINE/PubMed, SCOPUS, and Cochrane library from onset up to February 2019 to identify trials investigating the health effect of Medical nutrition (MNT) in patients with diabetes. Random-effects models were used to calculate the effect sizes as weighted mean difference (WMD) and 95% confidence intervals (CI). Results: Eleven studies containing 1227 participants were included in the meta-analysis. Pooled results showed a significant reduction in Fasting blood sugar (FBS) (WMD= −8.85 mg/dl, 95% CI: −14.41, −3.28), HbA1c (WMD: −0.43%, 95% CI: −0.69, −0.17), weight (WMD: −1.54 kg, 95% CI: −2.44, −0.64), Body mass index (BMI) (WMD: −0.34 Kg/m2, 95% CI: −0.52, −0.17), waist circumference (WMD: −2.16 cm, 95% CI: −4.09, −0.23), cholesterol (WMD: −4.06 mg/dl, 95% CI: −7.31, −0.81), Systolic blood pressure (SBP) (WMD: −7.90 mmHg, 95% CI: −13.03, −2.77). Results of meta-regression analysis based on age of participants and duration of intervention were not significant. Conclusions: Patients with diabetes who received medical nutrition therapy showed significant improvements in outcome measures of FBS, HbA1c, weight, BMI, waist circumference, cholesterol, and SBP.

    Original languageEnglish
    Pages (from-to)399-408
    Number of pages10
    JournalPrimary Care Diabetes
    Issue number5
    Early online date9 Jun 2019
    Publication statusPublished - 1 Oct 2019

    Bibliographical note

    NOTICE: this is the author’s version of a work that was accepted for publication in Primary Care Diabetes. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Primary Care Diabetes, Vol. 13, Iss. 5, (2019) DOI: 10.1016/j.pcd.2019.05.001

    © 2019, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International


    • Diabetes
    • Diet
    • Dietitians
    • Lifestyle
    • Nutrition therapy

    ASJC Scopus subject areas

    • Internal Medicine
    • Endocrinology, Diabetes and Metabolism
    • Nutrition and Dietetics


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