The Geometric Effects on the Stress of Arterial Atherosclerotic Plaques: A Computational Study

H. Liu, T. Leung, A. Wong, Fei Chen, D. Zheng

Research output: Chapter in Book/Report/Conference proceedingConference proceeding

Abstract

Background: The rupture of atherosclerotic plaques could cause serious clinical events. The wall shear stress (WSS) and axial plaque stress (APS) could reflect the risk of plaque rupture. This study aimed to quantitatively investigate the geometric effects on WSS and APS using computational fluid dynamics (CFD).Methods: 63 plaque models were developed from three severities (75%, 82%, and 89% in area), three eccentricities (the deviation of plaque throat from the arterial centerline: 0, 0.375 and 0.75mm), and 7 different length combinations of the proximal and distal stenotic segments (2mm-5mm, 3mm-5mm, 4mm-5mm, 5mm-5mm, 5mm-4mm, 5mm-3mm, 5mm-2mm). For each model, CFD simulation was performed to calculate the maximum and area-averaged WSS and APS on the proximal and distal stenotic segments. The multivariate analysis of variance and linear regression analysis were performed to quantitatively investigate the geometry-stress relationship.The results showed that, the severity and eccentricity of a plaque were linearly related to its WSS and APS. APS value on a segment (proximal or distal) of the plaque depended on the segmental length It was also shown that the difference of APS between proximal and distal segments depended exclusively on the difference of length between segments (all p<0.05).Conclusion: The geometry of a plaque influences its WSS and APS. APS and its proximal/distal difference depend on the segmental lengths.

Original languageEnglish
Title of host publication2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2019
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages6948-6951
Number of pages4
ISBN (Electronic)9781538613115
DOIs
Publication statusPublished - 1 Jul 2019
Externally publishedYes
Event41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society - Berlin, Germany
Duration: 23 Jul 201927 Jul 2019
Conference number: 41

Publication series

NameProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
ISSN (Print)1557-170X

Conference

Conference41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Abbreviated titleEMBC 2019
CountryGermany
CityBerlin
Period23/07/1927/07/19

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

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