The fat controller: roles of palmitoylation in intracellular protein trafficking and targeting to membrane microdomains (Review)

Jennifer Greaves; Gerald R Prescott; Oforiwa A Gorleku; Luke H Chamberlain

doi:10.1080/09687680802620351

The fat controller: roles of palmitoylation in intracellular protein trafficking and targeting to membrane microdomains (Review)

Jennifer Greaves, Gerald R Prescott, Oforiwa A Gorleku, Luke H Chamberlain

University of Edinburgh

Research output: Contribution to journal › Review article › peer-review

65 Citations (Scopus)

Abstract

The attachment of palmitic acid to the amino acid cysteine via thioester linkage (S-palmitoylation) is a common post-translational modification of eukaryotic proteins. In this review, we discuss the role of palmitoylation as a versatile protein sorting signal, regulating protein trafficking between distinct intracellular compartments and the micro-localization of proteins within membranes.

Original language	English
Pages (from-to)	67-79
Number of pages	13
Journal	Molecular Membrane Biology
Volume	26
Issue number	1
DOIs	https://doi.org/10.1080/09687680802620351
Publication status	Published - Jan 2009
Externally published	Yes

Keywords

Humans
Lipoylation
Membrane Microdomains
Protein Processing, Post-Translational
Protein Sorting Signals
Protein Transport
Proteins
Journal Article
Research Support, Non-U.S. Gov't
Review

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10.1080/09687680802620351

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abstract = "The attachment of palmitic acid to the amino acid cysteine via thioester linkage (S-palmitoylation) is a common post-translational modification of eukaryotic proteins. In this review, we discuss the role of palmitoylation as a versatile protein sorting signal, regulating protein trafficking between distinct intracellular compartments and the micro-localization of proteins within membranes.",

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AU - Chamberlain, Luke H

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AB - The attachment of palmitic acid to the amino acid cysteine via thioester linkage (S-palmitoylation) is a common post-translational modification of eukaryotic proteins. In this review, we discuss the role of palmitoylation as a versatile protein sorting signal, regulating protein trafficking between distinct intracellular compartments and the micro-localization of proteins within membranes.

KW - Humans

KW - Lipoylation

KW - Membrane Microdomains

KW - Protein Processing, Post-Translational

KW - Protein Sorting Signals

KW - Protein Transport

KW - Proteins

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

KW - Review

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ER -

The fat controller: roles of palmitoylation in intracellular protein trafficking and targeting to membrane microdomains (Review)

Abstract

Keywords

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