The fat controller: roles of palmitoylation in intracellular protein trafficking and targeting to membrane microdomains (Review)

Jennifer Greaves, Gerald R Prescott, Oforiwa A Gorleku, Luke H Chamberlain

Research output: Contribution to journalReview article

46 Citations (Scopus)

Abstract

The attachment of palmitic acid to the amino acid cysteine via thioester linkage (S-palmitoylation) is a common post-translational modification of eukaryotic proteins. In this review, we discuss the role of palmitoylation as a versatile protein sorting signal, regulating protein trafficking between distinct intracellular compartments and the micro-localization of proteins within membranes.

Original languageEnglish
Pages (from-to)67-79
Number of pages13
JournalMolecular Membrane Biology
Volume26
Issue number1
DOIs
Publication statusPublished - Jan 2009
Externally publishedYes

Fingerprint

Lipoylation
Membrane Microdomains
Protein Transport
Fats
Palmitic Acid
Post Translational Protein Processing
Protein Sorting Signals
Cysteine
Membrane Proteins
Amino Acids

Keywords

  • Humans
  • Lipoylation
  • Membrane Microdomains
  • Protein Processing, Post-Translational
  • Protein Sorting Signals
  • Protein Transport
  • Proteins
  • Journal Article
  • Research Support, Non-U.S. Gov't
  • Review

Cite this

The fat controller : roles of palmitoylation in intracellular protein trafficking and targeting to membrane microdomains (Review). / Greaves, Jennifer; Prescott, Gerald R; Gorleku, Oforiwa A; Chamberlain, Luke H.

In: Molecular Membrane Biology, Vol. 26, No. 1, 01.2009, p. 67-79.

Research output: Contribution to journalReview article

@article{88af6458d337465f9354988a4fe7cc8c,
title = "The fat controller: roles of palmitoylation in intracellular protein trafficking and targeting to membrane microdomains (Review)",
abstract = "The attachment of palmitic acid to the amino acid cysteine via thioester linkage (S-palmitoylation) is a common post-translational modification of eukaryotic proteins. In this review, we discuss the role of palmitoylation as a versatile protein sorting signal, regulating protein trafficking between distinct intracellular compartments and the micro-localization of proteins within membranes.",
keywords = "Humans, Lipoylation, Membrane Microdomains, Protein Processing, Post-Translational, Protein Sorting Signals, Protein Transport, Proteins, Journal Article, Research Support, Non-U.S. Gov't, Review",
author = "Jennifer Greaves and Prescott, {Gerald R} and Gorleku, {Oforiwa A} and Chamberlain, {Luke H}",
year = "2009",
month = "1",
doi = "10.1080/09687680802620351",
language = "English",
volume = "26",
pages = "67--79",
journal = "Molecular Membrane Biology",
issn = "0968-7688",
publisher = "Taylor & Francis",
number = "1",

}

TY - JOUR

T1 - The fat controller

T2 - roles of palmitoylation in intracellular protein trafficking and targeting to membrane microdomains (Review)

AU - Greaves, Jennifer

AU - Prescott, Gerald R

AU - Gorleku, Oforiwa A

AU - Chamberlain, Luke H

PY - 2009/1

Y1 - 2009/1

N2 - The attachment of palmitic acid to the amino acid cysteine via thioester linkage (S-palmitoylation) is a common post-translational modification of eukaryotic proteins. In this review, we discuss the role of palmitoylation as a versatile protein sorting signal, regulating protein trafficking between distinct intracellular compartments and the micro-localization of proteins within membranes.

AB - The attachment of palmitic acid to the amino acid cysteine via thioester linkage (S-palmitoylation) is a common post-translational modification of eukaryotic proteins. In this review, we discuss the role of palmitoylation as a versatile protein sorting signal, regulating protein trafficking between distinct intracellular compartments and the micro-localization of proteins within membranes.

KW - Humans

KW - Lipoylation

KW - Membrane Microdomains

KW - Protein Processing, Post-Translational

KW - Protein Sorting Signals

KW - Protein Transport

KW - Proteins

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

KW - Review

U2 - 10.1080/09687680802620351

DO - 10.1080/09687680802620351

M3 - Review article

VL - 26

SP - 67

EP - 79

JO - Molecular Membrane Biology

JF - Molecular Membrane Biology

SN - 0968-7688

IS - 1

ER -