The fat controller: roles of palmitoylation in intracellular protein trafficking and targeting to membrane microdomains (Review)

Jennifer Greaves, Gerald R Prescott, Oforiwa A Gorleku, Luke H Chamberlain

Research output: Contribution to journalReview article

51 Citations (Scopus)

Abstract

The attachment of palmitic acid to the amino acid cysteine via thioester linkage (S-palmitoylation) is a common post-translational modification of eukaryotic proteins. In this review, we discuss the role of palmitoylation as a versatile protein sorting signal, regulating protein trafficking between distinct intracellular compartments and the micro-localization of proteins within membranes.

Original languageEnglish
Pages (from-to)67-79
Number of pages13
JournalMolecular Membrane Biology
Volume26
Issue number1
DOIs
Publication statusPublished - Jan 2009
Externally publishedYes

Keywords

  • Humans
  • Lipoylation
  • Membrane Microdomains
  • Protein Processing, Post-Translational
  • Protein Sorting Signals
  • Protein Transport
  • Proteins
  • Journal Article
  • Research Support, Non-U.S. Gov't
  • Review

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