The efficiency of extraction of rutin from Sophora japonica is improved by ultrasound but is dependent on the solvent employed. Rutin is a compound with antioxidant activity and aqueous solvents appear to be unsuitable for ultrasonic extractions due to the formation of free radicals from the insonation of the solvent. The application of ultrasound to methanolic extraction gave a significant reduction in extraction time and an increase in maximum yield.
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Paniwnyk, L., Beaufoy, E., Lorimer, J. P., & Mason, T. J. (2001). The extraction of rutin from flower buds of Sophora japonica. Ultrasonics Sonochemistry, 8(3), 299-301. https://doi.org/10.1016/S1350-4177(00)00075-4