The Efficacy of Ginseng Supplementation on Plasma Lipid Concentration in Adults: A Systematic Review and Meta-Analysis

Rahele Ziaei , Abed Ghavami, Ehsan Ghaedi, Amir Hadi, Parisa Javadian , Cain Clark

    Research output: Contribution to journalArticlepeer-review

    8 Citations (Scopus)
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    Abstract

    Objective: We performed a meta-analysis to evaluate the efficacy of ginseng supplementation on plasma lipid concentration.

    Methods: The search included PubMed, Scopus, ISI Web of Science, Cochrane library, and Google Scholar (up to April 2019) to identify randomized controlled trials (RCTs) investigating the effect of ginseng supplementation on serum lipid parameters. To estimate the overall summary effect, we used random-effects model.

    Results: Twenty-seven studies comprising 35 treatment arms comprising 1245 participants fulfilled the inclusion criteria. The meta-analysis results showed that consumption of ginseng did not significantly change the concentrations of total cholesterol (TC), triglyceride (TG), low density lipoprotein-cholesterol (LDL-C), and high density lipoprotein-cholesterol (HDL-C). However, subgroup analyses showed a significant lowering effect in high dose ginseng supplementation on TC, LDL-C and TG. Also, the impact of ginseng on TC and TG was significant in long-term interventions.

    Conclusion: Further RCTs with longer supplementation durations in subjects with dyslipidemia are necessitated for a more robust assessment of the lipid-modulating properties of this plant.
    Original languageEnglish
    Article number102239
    JournalComplementary Therapies in Medicine
    Volume48
    Early online date7 Nov 2019
    DOIs
    Publication statusPublished - Jan 2020

    Keywords

    • Ginseng
    • Supplementation
    • Lipid profile
    • Systematic review
    • Meta-analysis

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