The efficacy and safety of zinc gluconate supplementation on quality of life, sleep quality, and serum albumin in hemodialysis patients: A randomized clinical trial

Sajjad Haddadian-Khouzani, Shahrzad Shahidi, Gholamreza Askari, Cain C.T. Clark, Mohammad Hossein Rouhani

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    Abstract

    Introduction Hemodialysis patients suffer from several conditions, including low quality of life, poor sleep quality, and decreased serum albumin. We hypothesized that zinc supplementation may improve these problems. The aim of the present study was to examine the effects of zinc gluconate supplementation on quality of life, sleep quality, and serum albumin. Methods In this parallel randomized clinical trial, 87 hemodialysis patients were randomly assigned in the zinc (n=44) or placebo group (n=43) for 12 weeks. Patients in the zinc group received one 30 mg zinc gluconate tablet per day. Quality of life was assessed The Kidney Disease Quality of Life (KDQOL) instrument, and sleep quality was evaluated by The Pittsburgh Sleep Questionnaire. Also, serum concentrations of albumin and high sensitivity C-reactive protein (hs-CRP) were measured at baseline and end of the study. Results There were beneficial effects of zinc supplementation on sleep quality (Effect (95% CI):-0.91(-1.34, -0.48)) and albumin concentration (Effect (95% CI): 0.327(0.06,0.59)), compared with placebo. However, we observed no changes in high-sensitivity C-reactive protein (Effect (95% CI): -6.59(-19.94,6.76)) and quality of life (Effect (95% CI): 0.17(-1.32,1.65) in zinc group in comparison with placebo. Also, we observed no adverse events from zinc supplementation in these patients. Conclusion This randomized clinical trial showed that zinc supplementation elicited beneficial effects on sleep quality and albumin levels in hemodialysis patients. This randomized clinical trial was registered at IRCT.ir (IRCT20130903014551N10).
    Original languageEnglish
    Article number102183
    Number of pages7
    JournalEuropean Journal of Integrative Medicine
    Volume55
    Early online date27 Aug 2022
    DOIs
    Publication statusPublished - Oct 2022

    Bibliographical note

    NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/

    Copyright © and Moral Rights are retained by the author(s) and/ or other copyright owners. A copy can be downloaded for personal non-commercial research or study, without prior permission or charge. This item cannot be reproduced or quoted extensively from without first obtaining permission in writing from the copyright holder(s). The content must not be changed in any way or sold commercially in any format or medium without the formal permission of the copyright holders.

    This document is the author’s post-print version, incorporating any revisions agreed during the peer-review process. Some differences between the published version and this version may remain and you are advised to consult the published version if you wish to cite from it.

    Funder

    This study was supported by Isfahan University of Medical Sciences. This is a research institute that provide fund for medical research. The funds are assigned to each researcher based on his/her previous researcher and CV. The funders had no role in the study design, data collection, and analysis, decision to publish, or preparation of the manuscript. Also, the funder had no relationship with pharmaceutical industries. There was no other financial support. All supplements and placebos were bought. No funding was provided by pharmaceutical companies. Also, we selected zinc supplementation based on the results of literature review but it was not offered by pharmaceutical companies. There was no COI between researchers and the zinc company.

    Keywords

    • Renal dialysis
    • Zinc
    • Sleep quality
    • Quality of life
    • Albumins
    • Randomized controlled trial

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