The effects of selenium supplementation on blood lipids and blood pressure in adults:  A systematic review and dose-response meta-analysis of randomized control trials

Mahnaz Rezaei Kelishadi; Damoon Ashtary-Larky; Sayed Hosein Davoodi; Cain C.T. Clark; Omid Asbaghi

doi:10.1016/j.jtemb.2022.127046

The effects of selenium supplementation on blood lipids and blood pressure in adults: A systematic review and dose-response meta-analysis of randomized control trials

Mahnaz Rezaei Kelishadi
, Damoon Ashtary-Larky
, Sayed Hosein Davoodi
, Cain C.T. Clark
, Omid Asbaghi

Isfahan University of Medical Sciences
Ahvaz Jundishapur University of Medical Sciences
Shahid Beheshti University of Medical Sciences

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

Background Previous studies evaluating the effects of selenium supplementation on lipid profile and blood pressure (BP) offer contradictory findings. This systematic review and meta-analysis assessed the effects of selenium supplementation on these lipid profile and BP. Methods In order to identify interrelated clinical trials, we performed a comprehensive literature search in the online databases, including PubMed, Scopus, Embase, and ISI web of science, up to December 2021. Results The analysis of the data established that selenium supplementation did not significantly affect TG level (WMD: -0.84mg/dL; 95% CI: -4.74, 3.05, p= 0.671), LDL-C (WMD: 0.86mg/dL; 95% CI: -1.21, 2.95, p= 0.416), and HDL-C (WMD: 0.3mg/dL; 95% CI: -0.66, 1.27, p= 0.535). however, there was a significant reduction in TC levels following selenium supplementation (WMD: -2.11mg/dL; 95% CI: -4.09, -0.13, p= 0.037). After subgroup analysis, when the baseline levels of LDL-C were

Original language	English
Article number	127046
Number of pages	31
Journal	Journal of Trace Elements in Medicine and Biology
Volume	74
Early online date	29 Jul 2022
DOIs	https://doi.org/10.1016/j.jtemb.2022.127046
Publication status	Published - Dec 2022

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Selenium
Lipid profile
Blood pressure
Cardiovascular disease
Systematic review
Meta-analysis

Access to Document

10.1016/j.jtemb.2022.127046

Cite this

Kelishadi, M. R., Ashtary-Larky, D., Davoodi, S. H., Clark, C. C. T., & Asbaghi, O. (2022). The effects of selenium supplementation on blood lipids and blood pressure in adults: A systematic review and dose-response meta-analysis of randomized control trials. Journal of Trace Elements in Medicine and Biology , 74, Article 127046. https://doi.org/10.1016/j.jtemb.2022.127046

The effects of selenium supplementation on blood lipids and blood pressure in adults: A systematic review and dose-response meta-analysis of randomized control trials. / Kelishadi, Mahnaz Rezaei; Ashtary-Larky, Damoon; Davoodi, Sayed Hosein et al.
In: Journal of Trace Elements in Medicine and Biology , Vol. 74, 127046, 12.2022.

Research output: Contribution to journal › Article › peer-review

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abstract = "Background Previous studies evaluating the effects of selenium supplementation on lipid profile and blood pressure (BP) offer contradictory findings. This systematic review and meta-analysis assessed the effects of selenium supplementation on these lipid profile and BP. Methods In order to identify interrelated clinical trials, we performed a comprehensive literature search in the online databases, including PubMed, Scopus, Embase, and ISI web of science, up to December 2021. Results The analysis of the data established that selenium supplementation did not significantly affect TG level (WMD: -0.84mg/dL; 95\% CI: -4.74, 3.05, p= 0.671), LDL-C (WMD: 0.86mg/dL; 95\% CI: -1.21, 2.95, p= 0.416), and HDL-C (WMD: 0.3mg/dL; 95\% CI: -0.66, 1.27, p= 0.535). however, there was a significant reduction in TC levels following selenium supplementation (WMD: -2.11mg/dL; 95\% CI: -4.09, -0.13, p= 0.037). After subgroup analysis, when the baseline levels of LDL-C were",

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