TY - JOUR
T1 - The effects of selenium supplementation on blood lipids and blood pressure in adults
T2 - A systematic review and dose-response meta-analysis of randomized control trials
AU - Kelishadi, Mahnaz Rezaei
AU - Ashtary-Larky, Damoon
AU - Davoodi, Sayed Hosein
AU - Clark, Cain C.T.
AU - Asbaghi, Omid
PY - 2022/12
Y1 - 2022/12
N2 - Background
Previous studies evaluating the effects of selenium supplementation on lipid profile and blood pressure (BP) offer contradictory findings. This systematic review and meta-analysis assessed the effects of selenium supplementation on these lipid profile and BP.
Methods
In order to identify interrelated clinical trials, we performed a comprehensive literature search in the online databases, including PubMed, Scopus, Embase, and ISI web of science, up to December 2021.
Results
The analysis of the data established that selenium supplementation did not significantly affect TG level (WMD: -0.84mg/dL; 95% CI: -4.74, 3.05, p= 0.671), LDL-C (WMD: 0.86mg/dL; 95% CI: -1.21, 2.95, p= 0.416), and HDL-C (WMD: 0.3mg/dL; 95% CI: -0.66, 1.27, p= 0.535). however, there was a significant reduction in TC levels following selenium supplementation (WMD: -2.11mg/dL; 95% CI: -4.09, -0.13, p= 0.037). After subgroup analysis, when the baseline levels of LDL-C were
AB - Background
Previous studies evaluating the effects of selenium supplementation on lipid profile and blood pressure (BP) offer contradictory findings. This systematic review and meta-analysis assessed the effects of selenium supplementation on these lipid profile and BP.
Methods
In order to identify interrelated clinical trials, we performed a comprehensive literature search in the online databases, including PubMed, Scopus, Embase, and ISI web of science, up to December 2021.
Results
The analysis of the data established that selenium supplementation did not significantly affect TG level (WMD: -0.84mg/dL; 95% CI: -4.74, 3.05, p= 0.671), LDL-C (WMD: 0.86mg/dL; 95% CI: -1.21, 2.95, p= 0.416), and HDL-C (WMD: 0.3mg/dL; 95% CI: -0.66, 1.27, p= 0.535). however, there was a significant reduction in TC levels following selenium supplementation (WMD: -2.11mg/dL; 95% CI: -4.09, -0.13, p= 0.037). After subgroup analysis, when the baseline levels of LDL-C were
KW - Selenium
KW - Lipid profile
KW - Blood pressure
KW - Cardiovascular disease
KW - Systematic review
KW - Meta-analysis
UR - http://www.scopus.com/inward/record.url?scp=85136563157&partnerID=8YFLogxK
U2 - 10.1016/j.jtemb.2022.127046
DO - 10.1016/j.jtemb.2022.127046
M3 - Article
SN - 0946-672X
VL - 74
JO - Journal of Trace Elements in Medicine and Biology
JF - Journal of Trace Elements in Medicine and Biology
M1 - 127046
ER -
