The effects of selenium supplementation on blood lipids and blood pressure in adults: A systematic review and dose-response meta-analysis of randomized control trials

Mahnaz Rezaei Kelishadi, Damoon Ashtary-Larky, Sayed Hosein Davoodi, Cain C.T. Clark, Omid Asbaghi

    Research output: Contribution to journalArticlepeer-review

    7 Citations (Scopus)

    Abstract

    Background Previous studies evaluating the effects of selenium supplementation on lipid profile and blood pressure (BP) offer contradictory findings. This systematic review and meta-analysis assessed the effects of selenium supplementation on these lipid profile and BP. Methods In order to identify interrelated clinical trials, we performed a comprehensive literature search in the online databases, including PubMed, Scopus, Embase, and ISI web of science, up to December 2021. Results The analysis of the data established that selenium supplementation did not significantly affect TG level (WMD: -0.84mg/dL; 95% CI: -4.74, 3.05, p= 0.671), LDL-C (WMD: 0.86mg/dL; 95% CI: -1.21, 2.95, p= 0.416), and HDL-C (WMD: 0.3mg/dL; 95% CI: -0.66, 1.27, p= 0.535). however, there was a significant reduction in TC levels following selenium supplementation (WMD: -2.11mg/dL; 95% CI: -4.09, -0.13, p= 0.037). After subgroup analysis, when the baseline levels of LDL-C were
    Original languageEnglish
    Article number127046
    Number of pages31
    JournalJournal of Trace Elements in Medicine and Biology
    Volume74
    Early online date29 Jul 2022
    DOIs
    Publication statusPublished - Dec 2022

    Keywords

    • Selenium
    • Lipid profile
    • Blood pressure
    • Cardiovascular disease
    • Systematic review
    • Meta-analysis

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