The effects of magnesium supplementation on abnormal uterine bleeding, alopecia, quality of life, and acne in women with polycystic ovary syndrome: a randomized clinical trial

Mahsima Jaripur, Hatav Ghasemi-Tehrani, Gholamreza Askari, Mahsa Gholizadeh-Moghaddam, Cain C. T. Clark, Mohammad Hossein Rouhani

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    Abstract

    Abstract: Background: Abnormal uterine bleeding (AUB), alopecia, low quality of life, and acne are considered as complications of polycystic ovary syndrome (PCOS). We hypothesized that magnesium supplementation would yield beneficial effects on PCOS related complications. Objective: To examine the effects of magnesium supplementation on AUB, alopecia, quality of life, and acne. Methods: In this parallel randomized clinical trial, we randomly assigned 64 women with PCOS to the magnesium group (n = 32) or placebo group (n = 32) for 10 weeks. AUB, alopecia, quality of life, and acne were assessed by the International Federation of Gynecology and Obstetrics criterion, the Sinclair Scale, the Health Survey Quality of Life Questionnaire, and the Global Acne Grading System, respectively. This randomized clinical trial was registered at IRCT.ir (IRCT20130903014551N9). Results: Magnesium supplementation significantly improved the components of quality of life including physical functioning (p = 0.011), role limitations due to physical health (p = 0.012), role limitations due to emotional problems (p < 0.001), energy/fatigue (p = 0.005), emotional wellbeing (p < 0.001), social functioning (p = 0.002), general health (p = 0.013), and total quality of life (p < 0.001), compared with placebo. No significant effect was observed on acne, alopecia, and AUB. Conclusion: Magnesium supplementation in women with PCOS had a significant positive effect on improving total quality of life. Trial registration: This randomized clinical trial was registered at IRCT.ir on 2020–10-18 (Registration Code: IRCT20130903014551N9).
    Original languageEnglish
    Article number110
    Number of pages11
    JournalReproductive Biology and Endocrinology
    Volume20
    Issue number1
    Early online date2 Aug 2022
    DOIs
    Publication statusE-pub ahead of print - 2 Aug 2022

    Bibliographical note

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    Keywords

    • Polycystic ovary syndrome
    • Magnesium
    • Acne
    • Quality of life
    • Alopecia
    • Abnormal uterine bleeding

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