The effects of magnesium supplementation on abnormal uterine bleeding, alopecia, quality of life, and acne in women with polycystic ovary syndrome:  a randomized clinical trial

Mahsima Jaripur; Hatav Ghasemi-Tehrani; Gholamreza Askari; Mahsa Gholizadeh-Moghaddam; Cain C. T. Clark; Mohammad Hossein Rouhani

doi:10.1186/s12958-022-00982-7

The effects of magnesium supplementation on abnormal uterine bleeding, alopecia, quality of life, and acne in women with polycystic ovary syndrome: a randomized clinical trial

Mahsima Jaripur, Hatav Ghasemi-Tehrani, Gholamreza Askari, Mahsa Gholizadeh-Moghaddam, Cain C. T. Clark, Mohammad Hossein Rouhani

Isfahan University of Medical Sciences

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

48 Downloads (Pure)

Abstract

Abstract: Background: Abnormal uterine bleeding (AUB), alopecia, low quality of life, and acne are considered as complications of polycystic ovary syndrome (PCOS). We hypothesized that magnesium supplementation would yield beneficial effects on PCOS related complications. Objective: To examine the effects of magnesium supplementation on AUB, alopecia, quality of life, and acne. Methods: In this parallel randomized clinical trial, we randomly assigned 64 women with PCOS to the magnesium group (n = 32) or placebo group (n = 32) for 10 weeks. AUB, alopecia, quality of life, and acne were assessed by the International Federation of Gynecology and Obstetrics criterion, the Sinclair Scale, the Health Survey Quality of Life Questionnaire, and the Global Acne Grading System, respectively. This randomized clinical trial was registered at IRCT.ir (IRCT20130903014551N9). Results: Magnesium supplementation significantly improved the components of quality of life including physical functioning (p = 0.011), role limitations due to physical health (p = 0.012), role limitations due to emotional problems (p < 0.001), energy/fatigue (p = 0.005), emotional wellbeing (p < 0.001), social functioning (p = 0.002), general health (p = 0.013), and total quality of life (p < 0.001), compared with placebo. No significant effect was observed on acne, alopecia, and AUB. Conclusion: Magnesium supplementation in women with PCOS had a significant positive effect on improving total quality of life. Trial registration: This randomized clinical trial was registered at IRCT.ir on 2020–10-18 (Registration Code: IRCT20130903014551N9).

Original language	English
Article number	110
Number of pages	11
Journal	Reproductive Biology and Endocrinology
Volume	20
Issue number	1
Early online date	2 Aug 2022
DOIs	https://doi.org/10.1186/s12958-022-00982-7
Publication status	E-pub ahead of print - 2 Aug 2022

Bibliographical note

This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the
original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.

Keywords

Polycystic ovary syndrome
Magnesium
Acne
Quality of life
Alopecia
Abnormal uterine bleeding

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Cite this

Jaripur, M., Ghasemi-Tehrani, H., Askari, G., Gholizadeh-Moghaddam, M., Clark, C. C. T., & Rouhani, M. H. (2022). The effects of magnesium supplementation on abnormal uterine bleeding, alopecia, quality of life, and acne in women with polycystic ovary syndrome: a randomized clinical trial. Reproductive Biology and Endocrinology, 20(1), Article 110. Advance online publication. https://doi.org/10.1186/s12958-022-00982-7

The effects of magnesium supplementation on abnormal uterine bleeding, alopecia, quality of life, and acne in women with polycystic ovary syndrome: a randomized clinical trial. / Jaripur, Mahsima; Ghasemi-Tehrani, Hatav; Askari, Gholamreza et al.
In: Reproductive Biology and Endocrinology, Vol. 20, No. 1, 110, 02.08.2022.

Research output: Contribution to journal › Article › peer-review

Jaripur, M, Ghasemi-Tehrani, H, Askari, G, Gholizadeh-Moghaddam, M, Clark, CCT & Rouhani, MH 2022, 'The effects of magnesium supplementation on abnormal uterine bleeding, alopecia, quality of life, and acne in women with polycystic ovary syndrome: a randomized clinical trial', Reproductive Biology and Endocrinology, vol. 20, no. 1, 110. https://doi.org/10.1186/s12958-022-00982-7

Jaripur M, Ghasemi-Tehrani H, Askari G, Gholizadeh-Moghaddam M, Clark CCT, Rouhani MH. The effects of magnesium supplementation on abnormal uterine bleeding, alopecia, quality of life, and acne in women with polycystic ovary syndrome: a randomized clinical trial. Reproductive Biology and Endocrinology. 2022 Aug 2;20(1):110. Epub 2022 Aug 2. doi: 10.1186/s12958-022-00982-7

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AU - Jaripur, Mahsima

AU - Ghasemi-Tehrani, Hatav

AU - Askari, Gholamreza

AU - Gholizadeh-Moghaddam, Mahsa

AU - Clark, Cain C. T.

AU - Rouhani, Mohammad Hossein

N1 - This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.

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N2 - Abstract: Background: Abnormal uterine bleeding (AUB), alopecia, low quality of life, and acne are considered as complications of polycystic ovary syndrome (PCOS). We hypothesized that magnesium supplementation would yield beneficial effects on PCOS related complications. Objective: To examine the effects of magnesium supplementation on AUB, alopecia, quality of life, and acne. Methods: In this parallel randomized clinical trial, we randomly assigned 64 women with PCOS to the magnesium group (n = 32) or placebo group (n = 32) for 10 weeks. AUB, alopecia, quality of life, and acne were assessed by the International Federation of Gynecology and Obstetrics criterion, the Sinclair Scale, the Health Survey Quality of Life Questionnaire, and the Global Acne Grading System, respectively. This randomized clinical trial was registered at IRCT.ir (IRCT20130903014551N9). Results: Magnesium supplementation significantly improved the components of quality of life including physical functioning (p = 0.011), role limitations due to physical health (p = 0.012), role limitations due to emotional problems (p < 0.001), energy/fatigue (p = 0.005), emotional wellbeing (p < 0.001), social functioning (p = 0.002), general health (p = 0.013), and total quality of life (p < 0.001), compared with placebo. No significant effect was observed on acne, alopecia, and AUB. Conclusion: Magnesium supplementation in women with PCOS had a significant positive effect on improving total quality of life. Trial registration: This randomized clinical trial was registered at IRCT.ir on 2020–10-18 (Registration Code: IRCT20130903014551N9).

AB - Abstract: Background: Abnormal uterine bleeding (AUB), alopecia, low quality of life, and acne are considered as complications of polycystic ovary syndrome (PCOS). We hypothesized that magnesium supplementation would yield beneficial effects on PCOS related complications. Objective: To examine the effects of magnesium supplementation on AUB, alopecia, quality of life, and acne. Methods: In this parallel randomized clinical trial, we randomly assigned 64 women with PCOS to the magnesium group (n = 32) or placebo group (n = 32) for 10 weeks. AUB, alopecia, quality of life, and acne were assessed by the International Federation of Gynecology and Obstetrics criterion, the Sinclair Scale, the Health Survey Quality of Life Questionnaire, and the Global Acne Grading System, respectively. This randomized clinical trial was registered at IRCT.ir (IRCT20130903014551N9). Results: Magnesium supplementation significantly improved the components of quality of life including physical functioning (p = 0.011), role limitations due to physical health (p = 0.012), role limitations due to emotional problems (p < 0.001), energy/fatigue (p = 0.005), emotional wellbeing (p < 0.001), social functioning (p = 0.002), general health (p = 0.013), and total quality of life (p < 0.001), compared with placebo. No significant effect was observed on acne, alopecia, and AUB. Conclusion: Magnesium supplementation in women with PCOS had a significant positive effect on improving total quality of life. Trial registration: This randomized clinical trial was registered at IRCT.ir on 2020–10-18 (Registration Code: IRCT20130903014551N9).

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