The effects of grape and red wine polyphenols on gut microbiota – A systematic review

Victoria Nash, C. Senaka Ranadheera, Ekavi N. Georgousopoulou, Duane D. Mellor, Demosthenes B. Panagiotakos, Andrew J. McKune, Jane Kellett, Nenad Naumovski

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

There is a growing body of evidence implicating the gut ‘microbiome’ role in overall human health. Bacterial species belonging to the genera Lactobacillus and Bifidobacterium are generally considered to be beneficial and are commonly used in probiotic applications, whereas increases in some genera including Clostridum, Eubacterium and Bacteroides are implicated in negative health outcomes. Dietary polyphenols are bioactive compounds that have been found to increase the numbers of beneficial bacteria and antimicrobial actions against pathogenic bacteria, however most studies have been conducted in animal models or in-vitro colonic models. The aim of this systematic review was to provide an overview of recent trials on the effect of dietary grape and red wine polyphenols on the gut microbiota in humans. Following PRISMA guidelines, a systematic review was conducted of electronic databases (PubMed, CINAHL, Cochrane Library, Wed of Science and Scopus) to identify human intervention trials examining the effect of grape or wine polyphenols on gut microbiota. Seven trials met the inclusion criteria. One study looked at changes in gut microbiota following the ingestion of de-alcoholised red wine or red wine, and six studies referred to gut microbiota as intermediates in formation of phenolic metabolites. All studies confirmed that ingested polyphenols from grape and red wine, were modulated by gut microbiota, increasing numbers of polyphenolic metabolites which were found in blood, urine, ileal fluid and faeces. Intake of polyphenols derived from grape and red wine can modulate gut microbiota and contribute to beneficial microbial ecology that can enhance human health benefits. Additionally, grape and red wine polyphenols were modulated by the gut microbiota and there is a potential for a two-way relationship between the gut microbiota and polyphenolic compounds. Nevertheless, additional research is required to fully understand the complex relationship between gut microbiota and dietary polyphenols before any health claims can be made in relation to human health.

Original languageEnglish
Pages (from-to)277-287
Number of pages11
JournalFood Research International
Volume113
Early online date11 Jul 2018
DOIs
Publication statusPublished - 1 Nov 2018

Fingerprint

Vitis
systematic review
Polyphenols
Wine
red wines
intestinal microorganisms
grapes
polyphenols
human health
Health
metabolites
Library Science
Gastrointestinal Microbiome
Eubacteria
Eubacterium
health claims
Bacteroides
Bacteria
microbial ecology
bacteria

Keywords

  • Gastrointestinal bacteria
  • Grape
  • Microbiota
  • Polyphenol metabolites
  • Polyphenols
  • Red wine

ASJC Scopus subject areas

  • Food Science

Cite this

Nash, V., Ranadheera, C. S., Georgousopoulou, E. N., Mellor, D. D., Panagiotakos, D. B., McKune, A. J., ... Naumovski, N. (2018). The effects of grape and red wine polyphenols on gut microbiota – A systematic review. Food Research International, 113, 277-287. https://doi.org/10.1016/j.foodres.2018.07.019

The effects of grape and red wine polyphenols on gut microbiota – A systematic review. / Nash, Victoria; Ranadheera, C. Senaka; Georgousopoulou, Ekavi N.; Mellor, Duane D.; Panagiotakos, Demosthenes B.; McKune, Andrew J.; Kellett, Jane; Naumovski, Nenad.

In: Food Research International, Vol. 113, 01.11.2018, p. 277-287.

Research output: Contribution to journalReview article

Nash, V, Ranadheera, CS, Georgousopoulou, EN, Mellor, DD, Panagiotakos, DB, McKune, AJ, Kellett, J & Naumovski, N 2018, 'The effects of grape and red wine polyphenols on gut microbiota – A systematic review' Food Research International, vol. 113, pp. 277-287. https://doi.org/10.1016/j.foodres.2018.07.019
Nash V, Ranadheera CS, Georgousopoulou EN, Mellor DD, Panagiotakos DB, McKune AJ et al. The effects of grape and red wine polyphenols on gut microbiota – A systematic review. Food Research International. 2018 Nov 1;113:277-287. https://doi.org/10.1016/j.foodres.2018.07.019
Nash, Victoria ; Ranadheera, C. Senaka ; Georgousopoulou, Ekavi N. ; Mellor, Duane D. ; Panagiotakos, Demosthenes B. ; McKune, Andrew J. ; Kellett, Jane ; Naumovski, Nenad. / The effects of grape and red wine polyphenols on gut microbiota – A systematic review. In: Food Research International. 2018 ; Vol. 113. pp. 277-287.
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