The effects of Cynara scolymus L. supplementation on liver enzymes: A systematic review and meta-analysis

Sajjad Moradi, Nafiseh Shokri-Mashhadi, Sahar Saraf-Bank, Hamed Mohammadi, Mehdi Zobeiri, Cain C.T. Clark, Mohammad Hossein Rouhani

    Research output: Contribution to journalArticlepeer-review

    7 Citations (Scopus)

    Abstract

    Objective: A systematic review and meta-analysis was conducted to summarise studies conducted on the effects of artichoke supplementation on liver enzymes. Methods: Suitable studies were detected by searching online databases, including Medline, Embase, Cochrane Library, and Scopus databases, until 05 June 2021. As liver enzymes were reported in different units, standardised mean differences (SMD) were used and data were pooled using a random-effects model. Heterogeneity, publication bias, and sensitivity analysis were also assessed. Results: Pooled analysis, of eight clinical trials, revealed that artichoke supplementation significantly reduced the concentration of aspartate aminotransferase (AST) (P =.001) and alanine transaminase (ALT) (P =.016), in comparison with placebo. Subgroup analysis suggested that artichoke administration significantly reduces AST and ALT in patients with non-alcoholic fatty liver disease (P =.003 for AST and P <.001 for ALT), and ALT among overweight/obese subjects (P =.025). Conclusions: Artichoke supplementation elicited significant reductions in liver enzymes, especially among patients with non-alcoholic fatty liver disease.

    Original languageEnglish
    Article numbere14726
    Number of pages9
    JournalInternational Journal of Clinical Practice
    Volume75
    Issue number11
    Early online date12 Aug 2021
    DOIs
    Publication statusPublished - Nov 2021

    Bibliographical note

    Publisher Copyright:
    © 2021 John Wiley & Sons Ltd

    Keywords

    • General Medicine

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