The effects of adjunctive treatment with l -carnitine on monitoring laboratory variables in ICU patients: a double-blinded randomized controlled clinical trial

Farveh Yahyapoor; Mahdi Keshani; Alireza Sedaghat; Awat Feizi; Cain C. T. Clark; Mohammad Bagherniya; Mohammad Safarian; Mohaddeseh Badpeyma; Abdolreza Norouzy

doi:10.1186/s13063-022-07010-4

The effects of adjunctive treatment with l -carnitine on monitoring laboratory variables in ICU patients: a double-blinded randomized controlled clinical trial

Farveh Yahyapoor, Mahdi Keshani, Alireza Sedaghat, Awat Feizi, Cain C. T. Clark, Mohammad Bagherniya, Mohammad Safarian, Mohaddeseh Badpeyma, Abdolreza Norouzy

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Abstract

Background: Critically ill patients must be monitored constantly in intensive care units (ICUs). Among many laboratory variables, nutritional status indicators are a key role in the prognosis of diseases. We investigated the effects of l-carnitine adjunctive therapy on monitoring variables in critical illness. Method: A prospective, double-blind, randomized controlled trial was implemented in a medical ICU. Participants were 54 patients, aged > 18 years, with multiple conditions, randomly assigned to receive 3 g l-carnitine per day or placebo, along with enteral feeding, for 1 week. Primary outcomes included monitoring variables related to nutritional status. Result: Of 54 patients randomly assigned, 51 completed the trial. Serum albumin (Alb) (P-value: 0.001), total protein (P-value: 0.003), and calcium (Ca) (0.044) significantly increased in the intervention vs. control group. Alanine transaminase (ALT) (0.022), lactate (

Original language	English
Article number	3
Number of pages	8
Journal	Trials
Volume	24
Issue number	1
DOIs	https://doi.org/10.1186/s13063-022-07010-4
Publication status	Published - 3 Jan 2023

Bibliographical note

© The Author(s) 2023. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativeco mmons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data

Keywords

Research
l-Carnitine
ICU
Nutritional status
Monitoring variable
Supplementation

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title = "The effects of adjunctive treatment with l -carnitine on monitoring laboratory variables in ICU patients: a double-blinded randomized controlled clinical trial",

abstract = "Background: Critically ill patients must be monitored constantly in intensive care units (ICUs). Among many laboratory variables, nutritional status indicators are a key role in the prognosis of diseases. We investigated the effects of l-carnitine adjunctive therapy on monitoring variables in critical illness. Method: A prospective, double-blind, randomized controlled trial was implemented in a medical ICU. Participants were 54 patients, aged > 18 years, with multiple conditions, randomly assigned to receive 3 g l-carnitine per day or placebo, along with enteral feeding, for 1 week. Primary outcomes included monitoring variables related to nutritional status. Result: Of 54 patients randomly assigned, 51 completed the trial. Serum albumin (Alb) (P-value: 0.001), total protein (P-value: 0.003), and calcium (Ca) (0.044) significantly increased in the intervention vs. control group. Alanine transaminase (ALT) (0.022), lactate (",

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AU - Bagherniya, Mohammad

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AU - Badpeyma, Mohaddeseh

AU - Norouzy, Abdolreza

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N2 - Background: Critically ill patients must be monitored constantly in intensive care units (ICUs). Among many laboratory variables, nutritional status indicators are a key role in the prognosis of diseases. We investigated the effects of l-carnitine adjunctive therapy on monitoring variables in critical illness. Method: A prospective, double-blind, randomized controlled trial was implemented in a medical ICU. Participants were 54 patients, aged > 18 years, with multiple conditions, randomly assigned to receive 3 g l-carnitine per day or placebo, along with enteral feeding, for 1 week. Primary outcomes included monitoring variables related to nutritional status. Result: Of 54 patients randomly assigned, 51 completed the trial. Serum albumin (Alb) (P-value: 0.001), total protein (P-value: 0.003), and calcium (Ca) (0.044) significantly increased in the intervention vs. control group. Alanine transaminase (ALT) (0.022), lactate (

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The effects of adjunctive treatment with l -carnitine on monitoring laboratory variables in ICU patients: a double-blinded randomized controlled clinical trial

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