The Effect of Vitamin D Supplementation on Insulin-Like Growth Factor-1: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Fatemeh Meshkini, Shima Abdollahi, Cain Clark, Sepideh Soltani

Research output: Contribution to journalArticle

Abstract


Purpose
There is equivocality regarding the interaction between vitamin D and insulin-like growth factor-1 (IGF-1). Thus, the aim of this study was to elucidate the effect of vitamin D supplementation on serum levels of IGF-1 by conducting a systematic review and meta-analysis of randomized controlled trials (RCTs).
Methods
PubMed, Scopus, and ISI Web of Science databases were searched up to May 2019 for RCTs that evaluated the effect of vitamin D supplementation on IGF-1 levels. Mean and standard deviation changes of IGF-1 in each treatment group were considered for analysis and pooled using random-effect model. Risk of bias for included studies was assessed by the Cochrane scale and the NutriGrade approach was applied to evaluate the quality of evidence.
Results
Six trials (n= 773 participants) were included in the meta-analysis. Compared with control group, vitamin D supplementation yielded no significant effect on serum level of IGF-1 (weighted mean difference [WMD] = 4.66 ng/ml, 95% CIs: -6.72 to 16.03, P=0.42, I2= 74.8, P-heterogeneity= 0.001). Additionally, no meaningful changes were observed in subgroup analyses.
Conclusion
The evidence from the limited number of published trials does not convincingly show that vitamin D supplementation elicits any clinically relevant effects on IGF-1 levels. More high-quality studies are needed to reach a consensual conclusion in this area.
Original languageEnglish
Article number102300
Pages (from-to)(In-Press)
JournalComplementary Therapies in Medicine
Volume(In-Press)
Early online date7 Jan 2020
DOIs
Publication statusE-pub ahead of print - 7 Jan 2020

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Somatomedins
Vitamin D
Meta-Analysis
Randomized Controlled Trials
Serum
Databases
Control Groups

Keywords

  • Growth factor
  • Insulin-Like Growth Factor-1
  • Meta-analysis
  • Vitamin D

Cite this

The Effect of Vitamin D Supplementation on Insulin-Like Growth Factor-1: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. / Meshkini, Fatemeh ; Abdollahi, Shima ; Clark, Cain; Soltani, Sepideh .

In: Complementary Therapies in Medicine, Vol. (In-Press), 102300, 07.01.2020, p. (In-Press).

Research output: Contribution to journalArticle

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abstract = "PurposeThere is equivocality regarding the interaction between vitamin D and insulin-like growth factor-1 (IGF-1). Thus, the aim of this study was to elucidate the effect of vitamin D supplementation on serum levels of IGF-1 by conducting a systematic review and meta-analysis of randomized controlled trials (RCTs).MethodsPubMed, Scopus, and ISI Web of Science databases were searched up to May 2019 for RCTs that evaluated the effect of vitamin D supplementation on IGF-1 levels. Mean and standard deviation changes of IGF-1 in each treatment group were considered for analysis and pooled using random-effect model. Risk of bias for included studies was assessed by the Cochrane scale and the NutriGrade approach was applied to evaluate the quality of evidence.ResultsSix trials (n= 773 participants) were included in the meta-analysis. Compared with control group, vitamin D supplementation yielded no significant effect on serum level of IGF-1 (weighted mean difference [WMD] = 4.66 ng/ml, 95{\%} CIs: -6.72 to 16.03, P=0.42, I2= 74.8, P-heterogeneity= 0.001). Additionally, no meaningful changes were observed in subgroup analyses.ConclusionThe evidence from the limited number of published trials does not convincingly show that vitamin D supplementation elicits any clinically relevant effects on IGF-1 levels. More high-quality studies are needed to reach a consensual conclusion in this area.",
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N2 - PurposeThere is equivocality regarding the interaction between vitamin D and insulin-like growth factor-1 (IGF-1). Thus, the aim of this study was to elucidate the effect of vitamin D supplementation on serum levels of IGF-1 by conducting a systematic review and meta-analysis of randomized controlled trials (RCTs).MethodsPubMed, Scopus, and ISI Web of Science databases were searched up to May 2019 for RCTs that evaluated the effect of vitamin D supplementation on IGF-1 levels. Mean and standard deviation changes of IGF-1 in each treatment group were considered for analysis and pooled using random-effect model. Risk of bias for included studies was assessed by the Cochrane scale and the NutriGrade approach was applied to evaluate the quality of evidence.ResultsSix trials (n= 773 participants) were included in the meta-analysis. Compared with control group, vitamin D supplementation yielded no significant effect on serum level of IGF-1 (weighted mean difference [WMD] = 4.66 ng/ml, 95% CIs: -6.72 to 16.03, P=0.42, I2= 74.8, P-heterogeneity= 0.001). Additionally, no meaningful changes were observed in subgroup analyses.ConclusionThe evidence from the limited number of published trials does not convincingly show that vitamin D supplementation elicits any clinically relevant effects on IGF-1 levels. More high-quality studies are needed to reach a consensual conclusion in this area.

AB - PurposeThere is equivocality regarding the interaction between vitamin D and insulin-like growth factor-1 (IGF-1). Thus, the aim of this study was to elucidate the effect of vitamin D supplementation on serum levels of IGF-1 by conducting a systematic review and meta-analysis of randomized controlled trials (RCTs).MethodsPubMed, Scopus, and ISI Web of Science databases were searched up to May 2019 for RCTs that evaluated the effect of vitamin D supplementation on IGF-1 levels. Mean and standard deviation changes of IGF-1 in each treatment group were considered for analysis and pooled using random-effect model. Risk of bias for included studies was assessed by the Cochrane scale and the NutriGrade approach was applied to evaluate the quality of evidence.ResultsSix trials (n= 773 participants) were included in the meta-analysis. Compared with control group, vitamin D supplementation yielded no significant effect on serum level of IGF-1 (weighted mean difference [WMD] = 4.66 ng/ml, 95% CIs: -6.72 to 16.03, P=0.42, I2= 74.8, P-heterogeneity= 0.001). Additionally, no meaningful changes were observed in subgroup analyses.ConclusionThe evidence from the limited number of published trials does not convincingly show that vitamin D supplementation elicits any clinically relevant effects on IGF-1 levels. More high-quality studies are needed to reach a consensual conclusion in this area.

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