The Effect of Valve Opening and Closing Time on the Mechano-Electric Feedback in the Left Ventricle

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Pathologies in the valves in the heart contribute to a large proportion of global cardiac deaths reduce the quality of lives for millions of others. Here, we investigate the effects of variations in the opening and closing times of the valves of the left ventricle at the same time as pathologies in the mechano-electric feedback. To this end, we utilize our synergistic cardio-vascular model without having to use time-varying elastance method. The latter prescribes the pressure-volume relationship in the ventricle directly using a periodic function, neglecting cardiac feedback and regulating mechanisms and is therefore unsuitable for investigating the mechano-electric feedback. We find that the closing time of valves has the greatest effect. A slower closing period of the aortic valve delays the onset of complications caused by the mechano-electric feedback, reducing the susceptibility to systolic stretch. For diastolic stretch, slow mitral valve closing time drastically increases the rise in heartrate and lessens the decline in stroke volume.

Original languageEnglish
Title of host publication10th E-Health and Bioengineering Conference Proceeding
PublisherInstitute of Electrical and Electronics Engineers Inc.
Number of pages4
ISBN (Electronic)9781665485579
ISBN (Print)9781665485586
Publication statusPublished - 2 Jan 2023
Event10th E-Health and Bioengineering Conference - Virtual, Romania
Duration: 17 Nov 202218 Nov 2022

Publication series

Name 10th E-Health and Bioengineering Conference, EHB 2022
ISSN (Electronic)2575-5145


Conference10th E-Health and Bioengineering Conference
Abbreviated titleEHB 2022

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  • Cardiovascular
  • heart valve
  • MEF
  • numerical modelling
  • valve motion

ASJC Scopus subject areas

  • Computer Science Applications
  • Biomedical Engineering
  • Health Informatics
  • Health(social science)


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