Abstract
Pathologies in the valves in the heart contribute to a large proportion of global cardiac deaths reduce the quality of lives for millions of others. Here, we investigate the effects of variations in the opening and closing times of the valves of the left ventricle at the same time as pathologies in the mechano-electric feedback. To this end, we utilize our synergistic cardio-vascular model without having to use time-varying elastance method. The latter prescribes the pressure-volume relationship in the ventricle directly using a periodic function, neglecting cardiac feedback and regulating mechanisms and is therefore unsuitable for investigating the mechano-electric feedback. We find that the closing time of valves has the greatest effect. A slower closing period of the aortic valve delays the onset of complications caused by the mechano-electric feedback, reducing the susceptibility to systolic stretch. For diastolic stretch, slow mitral valve closing time drastically increases the rise in heartrate and lessens the decline in stroke volume.
Original language | English |
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Title of host publication | 10th E-Health and Bioengineering Conference Proceeding |
Publisher | Institute of Electrical and Electronics Engineers Inc. |
Number of pages | 4 |
ISBN (Electronic) | 9781665485579 |
ISBN (Print) | 9781665485586 |
DOIs | |
Publication status | Published - 2 Jan 2023 |
Event | 10th E-Health and Bioengineering Conference - Virtual, Romania Duration: 17 Nov 2022 → 18 Nov 2022 |
Publication series
Name | 10th E-Health and Bioengineering Conference, EHB 2022 |
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Publisher | IEEE |
ISSN (Electronic) | 2575-5145 |
Conference
Conference | 10th E-Health and Bioengineering Conference |
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Abbreviated title | EHB 2022 |
Country/Territory | Romania |
Period | 17/11/22 → 18/11/22 |
Bibliographical note
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Keywords
- Cardiovascular
- heart valve
- MEF
- numerical modelling
- valve motion
ASJC Scopus subject areas
- Computer Science Applications
- Biomedical Engineering
- Health Informatics
- Health(social science)