The effect of synbiotic supplementation on atherogenic indices, hs-CRP, and malondialdehyde, as major CVD-related parameters, in women with gestational diabetes mellitus: a secondary data-analysis of a randomized double-blind, placebo-controlled study

Zohoor Nabhani; Cain C. T. Clark; Nazanin Goudarzi; Alemeh Hariri Far; Elham Razmpoosh

doi:10.1186/s13098-022-00858-1

The effect of synbiotic supplementation on atherogenic indices, hs-CRP, and malondialdehyde, as major CVD-related parameters, in women with gestational diabetes mellitus: a secondary data-analysis of a randomized double-blind, placebo-controlled study

Zohoor Nabhani, Cain C. T. Clark, Nazanin Goudarzi, Alemeh Hariri Far, Elham Razmpoosh

Research output: Contribution to journal › Article › peer-review

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Abstract

Women with GDM have a higher risk of future cardiovascular diseases (CVD). Meanwhile, synbiotics have been demonstrated to have favorable impacts on atherogenic indices, and inflammatory and oxidative stress indicators, all of which are known to be CVD-predictive factors. The aim of this randomized controlled trial was to evaluate the effects of synbiotic supplementation on the atherogenic indices of plasma, high-sensitivity C-reactive protein (hs-CRP), and plasma malondialdehyde (MDA) in women with GDM. Eligible pregnant women with GDM were randomized into two groups to receive a daily synbiotic capsule [500 mg of L.acidophilus(5 × 10 CFU/g), L.plantarum(1.5 × 10 CFU/g), L.fermentum(7 × 10 CFU/g), L.Gasseri(2 × 10 CFU/g) and 38.5 mg of fructo-oligo-saccharides], or placebo, for 6 weeks. The ratios of TC/HDL-C, LDL/HDL-C, and logTG/HDL-C were calculated as the atherogenic indices. Serum hs-CRP and MDA concentrations were quantified before and after the intervention. Cohen's d(d) was used to calculate the magnitude of the effect. Ninety participants completed the study. There was no significant difference in dietary antioxidant and mineral intakes between the two groups. Compared with placebo, synbiotic supplementation resulted in a significant decrease in logTG/HDL-C ratio with a medium-low effect size (mean difference = -0.11; 95% CI -0.21, 0; P values for the placebo and the intervention groups were 0.02, and 0.042, respectively; P between groups = 0.003; d = 0.25). No significant changes were observed in other parameters. Overall, 6 weeks of synbiotic supplementation in women with GDM resulted in a significant improvement in logTG/HDL-C, suggesting that synbiotics may have a beneficial role in reducing the risk of future CVDs associated with GDM. Nevertheless, more studies are needed to confirm the veracity of these results. Trial Registration IRCT201511183140N16 (December 29th, 2015). [Abstract copyright: © 2022. The Author(s).]

Original language	English
Article number	87
Number of pages	9
Journal	Diabetology & Metabolic Syndrome
Volume	14
Issue number	1
DOIs	https://doi.org/10.1186/s13098-022-00858-1
Publication status	Published - 21 Jun 2022

Bibliographical note

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or
other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativeco
mmons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

Funder

We would like to thank all the participants and staff members at Tabriz University of Medical Sciences, Tabriz, Iran. We thank Shahid Beheshti University of Medical Sciences for their executive support. We also express our gratitude to ZistTakhmir Co. for supplying synbiotic supplements (LactoFem). Funding Information: This study was funded by Tabriz University of Medical Sciences, Tabriz, Iran with code 62508

Keywords

Synbiotics
Diabetes
Gestational
Atherogenic Index of Plasma
Malondialdehyde
C-Reactive protein

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Nabhani, Z., Clark, C. C. T., Goudarzi, N., Hariri Far, A., & Razmpoosh, E. (2022). The effect of synbiotic supplementation on atherogenic indices, hs-CRP, and malondialdehyde, as major CVD-related parameters, in women with gestational diabetes mellitus: a secondary data-analysis of a randomized double-blind, placebo-controlled study. Diabetology & Metabolic Syndrome, 14(1), Article 87. https://doi.org/10.1186/s13098-022-00858-1

The effect of synbiotic supplementation on atherogenic indices, hs-CRP, and malondialdehyde, as major CVD-related parameters, in women with gestational diabetes mellitus: a secondary data-analysis of a randomized double-blind, placebo-controlled study. / Nabhani, Zohoor; Clark, Cain C. T.; Goudarzi, Nazanin et al.
In: Diabetology & Metabolic Syndrome, Vol. 14, No. 1, 87, 21.06.2022.

Research output: Contribution to journal › Article › peer-review

Nabhani, Z, Clark, CCT, Goudarzi, N, Hariri Far, A & Razmpoosh, E 2022, 'The effect of synbiotic supplementation on atherogenic indices, hs-CRP, and malondialdehyde, as major CVD-related parameters, in women with gestational diabetes mellitus: a secondary data-analysis of a randomized double-blind, placebo-controlled study', Diabetology & Metabolic Syndrome, vol. 14, no. 1, 87. https://doi.org/10.1186/s13098-022-00858-1

Nabhani Z, Clark CCT, Goudarzi N, Hariri Far A, Razmpoosh E. The effect of synbiotic supplementation on atherogenic indices, hs-CRP, and malondialdehyde, as major CVD-related parameters, in women with gestational diabetes mellitus: a secondary data-analysis of a randomized double-blind, placebo-controlled study. Diabetology & Metabolic Syndrome. 2022 Jun 21;14(1):87. doi: 10.1186/s13098-022-00858-1

Nabhani, Zohoor ; Clark, Cain C. T. ; Goudarzi, Nazanin et al. / The effect of synbiotic supplementation on atherogenic indices, hs-CRP, and malondialdehyde, as major CVD-related parameters, in women with gestational diabetes mellitus : a secondary data-analysis of a randomized double-blind, placebo-controlled study. In: Diabetology & Metabolic Syndrome. 2022 ; Vol. 14, No. 1.

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The effect of synbiotic supplementation on atherogenic indices, hs-CRP, and malondialdehyde, as major CVD-related parameters, in women with gestational diabetes mellitus: a secondary data-analysis of a randomized double-blind, placebo-controlled study

Abstract

Bibliographical note

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Keywords

UN SDGs

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