The effect of synbiotic supplementation on atherogenic indices, hs-CRP, and malondialdehyde, as major CVD-related parameters, in women with gestational diabetes mellitus: a secondary data-analysis of a randomized double-blind, placebo-controlled study

Zohoor Nabhani, Cain C. T. Clark, Nazanin Goudarzi, Alemeh Hariri Far, Elham Razmpoosh

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Abstract

Women with GDM have a higher risk of future cardiovascular diseases (CVD). Meanwhile, synbiotics have been demonstrated to have favorable impacts on atherogenic indices, and inflammatory and oxidative stress indicators, all of which are known to be CVD-predictive factors. The aim of this randomized controlled trial was to evaluate the effects of synbiotic supplementation on the atherogenic indices of plasma, high-sensitivity C-reactive protein (hs-CRP), and plasma malondialdehyde (MDA) in women with GDM. Eligible pregnant women with GDM were randomized into two groups to receive a daily synbiotic capsule [500 mg of L.acidophilus(5 × 10 CFU/g), L.plantarum(1.5 × 10 CFU/g), L.fermentum(7 × 10 CFU/g), L.Gasseri(2 × 10 CFU/g) and 38.5 mg of fructo-oligo-saccharides], or placebo, for 6 weeks. The ratios of TC/HDL-C, LDL/HDL-C, and logTG/HDL-C were calculated as the atherogenic indices. Serum hs-CRP and MDA concentrations were quantified before and after the intervention. Cohen's d(d) was used to calculate the magnitude of the effect. Ninety participants completed the study. There was no significant difference in dietary antioxidant and mineral intakes between the two groups. Compared with placebo, synbiotic supplementation resulted in a significant decrease in logTG/HDL-C ratio with a medium-low effect size (mean difference = -0.11; 95% CI -0.21, 0; P values for the placebo and the intervention groups were 0.02, and 0.042, respectively; P between groups = 0.003; d = 0.25). No significant changes were observed in other parameters. Overall, 6 weeks of synbiotic supplementation in women with GDM resulted in a significant improvement in logTG/HDL-C, suggesting that synbiotics may have a beneficial role in reducing the risk of future CVDs associated with GDM. Nevertheless, more studies are needed to confirm the veracity of these results. Trial Registration IRCT201511183140N16 (December 29th, 2015). [Abstract copyright: © 2022. The Author(s).]
Original languageEnglish
Article number87
Number of pages9
JournalDiabetology & Metabolic Syndrome
Volume14
Issue number1
DOIs
Publication statusPublished - 21 Jun 2022

Bibliographical note

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or
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Funder

We would like to thank all the participants and staff members at Tabriz University of Medical Sciences, Tabriz, Iran. We thank Shahid Beheshti University of Medical Sciences for their executive support. We also express our gratitude to ZistTakhmir Co. for supplying synbiotic supplements (LactoFem). Funding Information: This study was funded by Tabriz University of Medical Sciences, Tabriz, Iran with code 62508

Keywords

  • Synbiotics
  • Diabetes
  • Gestational
  • Atherogenic Index of Plasma
  • Malondialdehyde
  • C-Reactive protein

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