TY - JOUR
T1 - The effect of spirulina on type 2 diabetes
T2 - a systematic review and meta-analysis
AU - Hatami, Elaheh
AU - Ghalishourani, Samira Sadat
AU - Najafgholizadeh, Ameneh
AU - Pourmasoumi, Makan
AU - Hadi, Amir
AU - Clark, Cain C.T.
AU - Assaroudi, Mostafa
AU - Salehi-sahlabadi, Ammar
AU - Joukar, Farahnaz
AU - Mansour-Ghanaei, Fariborz
PY - 2021/6
Y1 - 2021/6
N2 - Purpose: The aim of the present study was to investigate the effect of spirulina on lipid profiles and glycemic related markers in type 2 diabetes patients. Methods: PubMed, Scopus, Cochrane Library, ISI Web of Science, and Google Scholar were searched from inception to August 2020. All clinical trials which investigated the effect of spirulina supplementation on glycemic related markers and lipid profile among type 2 diabetes patients were included. Random effects modeling was utilized for pooling analysis to compensate for the between-study heterogeneity. Results: Eight studies (9 arms) were included in the meta-analysis. We found a significant reduction in fasting blood glucose (−17.88 mg/dl; 95% CI: −26.99, −8.78; I2: 25%), triglyceride (−30.99 mg/dl; 95% CI: −45.20, −16.77; I2: 50%), total-cholesterol (−18.47 mg/dl; 95% CI: −33.54, −3.39; I2: 73%), LDL-C (−20.04 mg/dl; 95% CI: −34.06, −6.02; I2: 75%), VLDL (−6.96 mg/dl; 95% CI: −9.71, −4.22; I2: 33%), in addition to a significant increase in HDL-C (−6.96 mg/dl; 95% CI: −9.71, −4.22; I2: 33%), after spirulina administration. No significant effect was observed on HbA1C or post prandial blood sugar following spirulina consumption. Conclusion: The present study suggests that spirulina supplementation can elicit beneficial effects on fasting blood glucose and blood lipid profiles.
AB - Purpose: The aim of the present study was to investigate the effect of spirulina on lipid profiles and glycemic related markers in type 2 diabetes patients. Methods: PubMed, Scopus, Cochrane Library, ISI Web of Science, and Google Scholar were searched from inception to August 2020. All clinical trials which investigated the effect of spirulina supplementation on glycemic related markers and lipid profile among type 2 diabetes patients were included. Random effects modeling was utilized for pooling analysis to compensate for the between-study heterogeneity. Results: Eight studies (9 arms) were included in the meta-analysis. We found a significant reduction in fasting blood glucose (−17.88 mg/dl; 95% CI: −26.99, −8.78; I2: 25%), triglyceride (−30.99 mg/dl; 95% CI: −45.20, −16.77; I2: 50%), total-cholesterol (−18.47 mg/dl; 95% CI: −33.54, −3.39; I2: 73%), LDL-C (−20.04 mg/dl; 95% CI: −34.06, −6.02; I2: 75%), VLDL (−6.96 mg/dl; 95% CI: −9.71, −4.22; I2: 33%), in addition to a significant increase in HDL-C (−6.96 mg/dl; 95% CI: −9.71, −4.22; I2: 33%), after spirulina administration. No significant effect was observed on HbA1C or post prandial blood sugar following spirulina consumption. Conclusion: The present study suggests that spirulina supplementation can elicit beneficial effects on fasting blood glucose and blood lipid profiles.
KW - Arthrospira platensis
KW - Diabetes mellitus
KW - Meta-analysis
KW - Spirulina
UR - http://www.scopus.com/inward/record.url?scp=85102026124&partnerID=8YFLogxK
U2 - 10.1007/s40200-021-00760-z
DO - 10.1007/s40200-021-00760-z
M3 - Review article
AN - SCOPUS:85102026124
VL - 20
SP - 883
EP - 892
JO - Journal of Diabetes and Metabolic Disorders
JF - Journal of Diabetes and Metabolic Disorders
SN - 2251-6581
IS - 1
ER -