The effect of spirulina on type 2 diabetes: a systematic review and meta-analysis

Elaheh Hatami; Samira Sadat Ghalishourani; Ameneh Najafgholizadeh; Makan Pourmasoumi; Amir Hadi; Cain C.T. Clark; Mostafa Assaroudi; Ammar Salehi-sahlabadi; Farahnaz Joukar; Fariborz Mansour-Ghanaei

doi:10.1007/s40200-021-00760-z

The effect of spirulina on type 2 diabetes: a systematic review and meta-analysis

Elaheh Hatami, Samira Sadat Ghalishourani, Ameneh Najafgholizadeh, Makan Pourmasoumi, Amir Hadi, Cain C.T. Clark, Mostafa Assaroudi, Ammar Salehi-sahlabadi, Farahnaz Joukar, Fariborz Mansour-Ghanaei

Research output: Contribution to journal › Review article › peer-review

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Abstract

Purpose: The aim of the present study was to investigate the effect of spirulina on lipid profiles and glycemic related markers in type 2 diabetes patients. Methods: PubMed, Scopus, Cochrane Library, ISI Web of Science, and Google Scholar were searched from inception to August 2020. All clinical trials which investigated the effect of spirulina supplementation on glycemic related markers and lipid profile among type 2 diabetes patients were included. Random effects modeling was utilized for pooling analysis to compensate for the between-study heterogeneity. Results: Eight studies (9 arms) were included in the meta-analysis. We found a significant reduction in fasting blood glucose (−17.88 mg/dl; 95% CI: −26.99, −8.78; I²: 25%), triglyceride (−30.99 mg/dl; 95% CI: −45.20, −16.77; I²: 50%), total-cholesterol (−18.47 mg/dl; 95% CI: −33.54, −3.39; I²: 73%), LDL-C (−20.04 mg/dl; 95% CI: −34.06, −6.02; I²: 75%), VLDL (−6.96 mg/dl; 95% CI: −9.71, −4.22; I²: 33%), in addition to a significant increase in HDL-C (−6.96 mg/dl; 95% CI: −9.71, −4.22; I²: 33%), after spirulina administration. No significant effect was observed on HbA1C or post prandial blood sugar following spirulina consumption. Conclusion: The present study suggests that spirulina supplementation can elicit beneficial effects on fasting blood glucose and blood lipid profiles.

Original language	English
Pages (from-to)	883-892
Number of pages	10
Journal	Journal of Diabetes and Metabolic Disorders
Volume	20
Issue number	1
Early online date	2 Mar 2021
DOIs	https://doi.org/10.1007/s40200-021-00760-z
Publication status	Published - Jun 2021

Bibliographical note

The final publication is available at Springer via http://dx.doi.org/10.1007/s40200-021-00760-z

Copyright © and Moral Rights are retained by the author(s) and/ or other copyright owners. A copy can be downloaded for personal non-commercial research or study, without prior permission or charge. This item cannot be reproduced or quoted extensively from without first obtaining permission in writing from the copyright holder(s). The content must not be changed in any way or sold commercially in any format or medium without the formal permission of the copyright holders.

Keywords

Arthrospira platensis
Diabetes mellitus
Meta-analysis
Spirulina

ASJC Scopus subject areas

Internal Medicine
Endocrinology, Diabetes and Metabolism

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/s40200-021-00760-z

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Cite this

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title = "The effect of spirulina on type 2 diabetes: a systematic review and meta-analysis",

abstract = "Purpose: The aim of the present study was to investigate the effect of spirulina on lipid profiles and glycemic related markers in type 2 diabetes patients. Methods: PubMed, Scopus, Cochrane Library, ISI Web of Science, and Google Scholar were searched from inception to August 2020. All clinical trials which investigated the effect of spirulina supplementation on glycemic related markers and lipid profile among type 2 diabetes patients were included. Random effects modeling was utilized for pooling analysis to compensate for the between-study heterogeneity. Results: Eight studies (9 arms) were included in the meta-analysis. We found a significant reduction in fasting blood glucose (−17.88 mg/dl; 95% CI: −26.99, −8.78; I2: 25%), triglyceride (−30.99 mg/dl; 95% CI: −45.20, −16.77; I2: 50%), total-cholesterol (−18.47 mg/dl; 95% CI: −33.54, −3.39; I2: 73%), LDL-C (−20.04 mg/dl; 95% CI: −34.06, −6.02; I2: 75%), VLDL (−6.96 mg/dl; 95% CI: −9.71, −4.22; I2: 33%), in addition to a significant increase in HDL-C (−6.96 mg/dl; 95% CI: −9.71, −4.22; I2: 33%), after spirulina administration. No significant effect was observed on HbA1C or post prandial blood sugar following spirulina consumption. Conclusion: The present study suggests that spirulina supplementation can elicit beneficial effects on fasting blood glucose and blood lipid profiles.",

keywords = "Arthrospira platensis, Diabetes mellitus, Meta-analysis, Spirulina",

author = "Elaheh Hatami and Ghalishourani, {Samira Sadat} and Ameneh Najafgholizadeh and Makan Pourmasoumi and Amir Hadi and Clark, {Cain C.T.} and Mostafa Assaroudi and Ammar Salehi-sahlabadi and Farahnaz Joukar and Fariborz Mansour-Ghanaei",

note = "The final publication is available at Springer via http://dx.doi.org/10.1007/s40200-021-00760-z Copyright {\textcopyright} and Moral Rights are retained by the author(s) and/ or other copyright owners. A copy can be downloaded for personal non-commercial research or study, without prior permission or charge. This item cannot be reproduced or quoted extensively from without first obtaining permission in writing from the copyright holder(s). The content must not be changed in any way or sold commercially in any format or medium without the formal permission of the copyright holders. ",

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month = jun,

doi = "10.1007/s40200-021-00760-z",

language = "English",

volume = "20",

pages = "883--892",

journal = "Journal of Diabetes and Metabolic Disorders",

issn = "2251-6581",

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T1 - The effect of spirulina on type 2 diabetes

T2 - a systematic review and meta-analysis

AU - Hatami, Elaheh

AU - Ghalishourani, Samira Sadat

AU - Najafgholizadeh, Ameneh

AU - Pourmasoumi, Makan

AU - Hadi, Amir

AU - Clark, Cain C.T.

AU - Assaroudi, Mostafa

AU - Salehi-sahlabadi, Ammar

AU - Joukar, Farahnaz

AU - Mansour-Ghanaei, Fariborz

N1 - The final publication is available at Springer via http://dx.doi.org/10.1007/s40200-021-00760-z Copyright © and Moral Rights are retained by the author(s) and/ or other copyright owners. A copy can be downloaded for personal non-commercial research or study, without prior permission or charge. This item cannot be reproduced or quoted extensively from without first obtaining permission in writing from the copyright holder(s). The content must not be changed in any way or sold commercially in any format or medium without the formal permission of the copyright holders.

PY - 2021/6

Y1 - 2021/6

N2 - Purpose: The aim of the present study was to investigate the effect of spirulina on lipid profiles and glycemic related markers in type 2 diabetes patients. Methods: PubMed, Scopus, Cochrane Library, ISI Web of Science, and Google Scholar were searched from inception to August 2020. All clinical trials which investigated the effect of spirulina supplementation on glycemic related markers and lipid profile among type 2 diabetes patients were included. Random effects modeling was utilized for pooling analysis to compensate for the between-study heterogeneity. Results: Eight studies (9 arms) were included in the meta-analysis. We found a significant reduction in fasting blood glucose (−17.88 mg/dl; 95% CI: −26.99, −8.78; I2: 25%), triglyceride (−30.99 mg/dl; 95% CI: −45.20, −16.77; I2: 50%), total-cholesterol (−18.47 mg/dl; 95% CI: −33.54, −3.39; I2: 73%), LDL-C (−20.04 mg/dl; 95% CI: −34.06, −6.02; I2: 75%), VLDL (−6.96 mg/dl; 95% CI: −9.71, −4.22; I2: 33%), in addition to a significant increase in HDL-C (−6.96 mg/dl; 95% CI: −9.71, −4.22; I2: 33%), after spirulina administration. No significant effect was observed on HbA1C or post prandial blood sugar following spirulina consumption. Conclusion: The present study suggests that spirulina supplementation can elicit beneficial effects on fasting blood glucose and blood lipid profiles.

AB - Purpose: The aim of the present study was to investigate the effect of spirulina on lipid profiles and glycemic related markers in type 2 diabetes patients. Methods: PubMed, Scopus, Cochrane Library, ISI Web of Science, and Google Scholar were searched from inception to August 2020. All clinical trials which investigated the effect of spirulina supplementation on glycemic related markers and lipid profile among type 2 diabetes patients were included. Random effects modeling was utilized for pooling analysis to compensate for the between-study heterogeneity. Results: Eight studies (9 arms) were included in the meta-analysis. We found a significant reduction in fasting blood glucose (−17.88 mg/dl; 95% CI: −26.99, −8.78; I2: 25%), triglyceride (−30.99 mg/dl; 95% CI: −45.20, −16.77; I2: 50%), total-cholesterol (−18.47 mg/dl; 95% CI: −33.54, −3.39; I2: 73%), LDL-C (−20.04 mg/dl; 95% CI: −34.06, −6.02; I2: 75%), VLDL (−6.96 mg/dl; 95% CI: −9.71, −4.22; I2: 33%), in addition to a significant increase in HDL-C (−6.96 mg/dl; 95% CI: −9.71, −4.22; I2: 33%), after spirulina administration. No significant effect was observed on HbA1C or post prandial blood sugar following spirulina consumption. Conclusion: The present study suggests that spirulina supplementation can elicit beneficial effects on fasting blood glucose and blood lipid profiles.

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KW - Diabetes mellitus

KW - Meta-analysis

KW - Spirulina

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SN - 2251-6581

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JO - Journal of Diabetes and Metabolic Disorders

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ER -

The effect of spirulina on type 2 diabetes: a systematic review and meta-analysis

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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