Abstract
Purpose: The aim of the present study was to investigate the effect of spirulina on lipid profiles and glycemic related markers in type 2 diabetes patients. Methods: PubMed, Scopus, Cochrane Library, ISI Web of Science, and Google Scholar were searched from inception to August 2020. All clinical trials which investigated the effect of spirulina supplementation on glycemic related markers and lipid profile among type 2 diabetes patients were included. Random effects modeling was utilized for pooling analysis to compensate for the between-study heterogeneity. Results: Eight studies (9 arms) were included in the meta-analysis. We found a significant reduction in fasting blood glucose (−17.88 mg/dl; 95% CI: −26.99, −8.78; I2: 25%), triglyceride (−30.99 mg/dl; 95% CI: −45.20, −16.77; I2: 50%), total-cholesterol (−18.47 mg/dl; 95% CI: −33.54, −3.39; I2: 73%), LDL-C (−20.04 mg/dl; 95% CI: −34.06, −6.02; I2: 75%), VLDL (−6.96 mg/dl; 95% CI: −9.71, −4.22; I2: 33%), in addition to a significant increase in HDL-C (−6.96 mg/dl; 95% CI: −9.71, −4.22; I2: 33%), after spirulina administration. No significant effect was observed on HbA1C or post prandial blood sugar following spirulina consumption. Conclusion: The present study suggests that spirulina supplementation can elicit beneficial effects on fasting blood glucose and blood lipid profiles.
Original language | English |
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Pages (from-to) | 883-892 |
Number of pages | 10 |
Journal | Journal of Diabetes and Metabolic Disorders |
Volume | 20 |
Issue number | 1 |
Early online date | 2 Mar 2021 |
DOIs | |
Publication status | Published - Jun 2021 |
Bibliographical note
The final publication is available at Springer via http://dx.doi.org/10.1007/s40200-021-00760-zCopyright © and Moral Rights are retained by the author(s) and/ or other copyright owners. A copy can be downloaded for personal non-commercial research or study, without prior permission or charge. This item cannot be reproduced or quoted extensively from without first obtaining permission in writing from the copyright holder(s). The content must not be changed in any way or sold commercially in any format or medium without the formal permission of the copyright holders.
Keywords
- Arthrospira platensis
- Diabetes mellitus
- Meta-analysis
- Spirulina
ASJC Scopus subject areas
- Internal Medicine
- Endocrinology, Diabetes and Metabolism